基于代谢组学的杀菌剂作用机理研究  

Study on Antifungal Modes-of-Action Based on Metabolomics

作　　者：陈溪 纪明山 

机构地区：[1]忱阳农业大学植物保护学院,沈阳110866 [2]大连出入境检验检疫局检验检疫技术中心,116400

出　　处：《农药》2013年第4期235-237,257,共4页Agrochemicals

基　　金：国家自然科学基金(31071746)

摘　　要：目前代谢组学是生物活性物质高效筛选的重要工具,在生命科学领域得到了越来越广泛的应用并展现出良好的前景。综述了代谢组学的概念、实验方法、分析方法、数据处理以及在生物、医药领域的应用及农药学领域的研究前景。并在此基础上,提出了利用代谢组学研究杀菌剂作用机理可能的发展方向。以高通量检测和数据处理为手段,建立代谢指纹图谱库,创建一个可以快速筛查未知杀菌剂作用机理的方法,在新型农药的研制、毒理学分析、安全评价等领域具有广阔的前景,将成为农药现代研究的一个重要突破口。Metabolomics had so far been a valuable high-throughput screening tool for bioactive substances, and it was widely applied to life science and showed a promising perspective. The concept, empirical method, analytical method,data processing, application of metabolomics was summarized, and its potentials in biology, medicine, pesticide sphere were prospected. In this foundation, the development direction through the studies on antifungal metabolomics wasrised. Through high-throughput screening and data processing as device, metabolic fingerprint library was established, and a method which can quickly screen unknown modes-of-action antifungal was set up. Metabolomics has importantfuture trends in new drug research, drug toxicology analysis and assessment, and it might be a important breakthrough in pesticide study.

关 键 词：代谢组学 杀菌剂 作用机理 代谢指纹图谱分析 

分 类 号：TQ455.4[化学工程—农药化工]