除草剂Methiozolin的合成与生物活性  

Synthesis and Herbicidal Activity Study of Methiozolin

作　　者：杨桂秋[1,2] 焦爽[1,2] 李青[1,2] 马宏娟[2] 

机构地区：[1]沈阳化工大学,沈阳110142 [2]沈阳化工研究院有限公司新农药创制与开发国家重点实验室,沈阳110021

出　　处：《农药》2013年第4期247-248,共2页Agrochemicals

基　　金：国家重点基础研究发展规划项目(973项目:2010CB126105;2012CB724501);国家"十二五"科技支撑计划项目(2011BAE06B00;2011BAE06B01;2011BAE06B02;2011BAE06B03;2011BAE06B05)

摘　　要：[目的]Methiozolin是韩国化学技术研究所开发的异唑啉类除草剂,为了研究其除草活性,探索了其合成方法并进行了生物活性测试。[方法]以3-甲基噻吩醛为起始原料,与盐酸羟胺反应制得肟,再经氯化、合环,最后与苄氯反应得到目标产物。[结果]表明该化合物具有良好除草活性且对水稻、小麦安全。[Aims] Methiozolin as a novel herbicide was developed by Korea Research Institute of Chemical Technology. In oder to study the herbicidal activity of methiozolin, the synthetic method and herbicidal activity were explored. [Methods] Methiozolin was synthesized by reacting 3-methylthiophene-2-carbaldehyde with hydroxylamine hydrochloride, and then chlorination, ring closing to get the target product. [Results] The herbicidal activity result shows that methiozolin has good herbicidal activity and at the recommended rate of application the rice and wheat is safe.

关 键 词：methiozolin 合成 除草活性 安全性 

分 类 号：TQ457.2[化学工程—农药化工]