盐酸阿比朵尔在大鼠体内的分布与排泄研究  

Distribution and excretion of arbidol hydrochloride in rats

作　　者：刘晓[1,2,3] 裴科[1,2] 陈晓辉[3] 毕开顺[3] 

机构地区：[1]南京中医药大学药学院,南京210029 [2]南京中医药大学江苏省中药炮制重点实验室,南京210029 [3]沈阳药科大学药学院,沈阳110016

出　　处：《中国新药杂志》2013年第7期829-833,共5页Chinese Journal of New Drugs

摘　　要：目的:研究盐酸阿比朵尔在大鼠体内的分布与排泄情况。方法:大鼠单次灌胃给予盐酸阿比朵尔54 mg.kg-1,5,15,360 min摘取组织,并收集粪便、尿、胆汁等样品,应用LC/MS方法检测药物浓度。结果:给药5 min后,各组织中即可检测到药物。在消化道主要器官和肺、肝、脾等靶器官中,药物分布水平均较高。给药后72 h内,原型药物在粪便中累积排泄量为(2 018±578)μg;在尿液中为(2 858±1 744)ng。在胆汁中0～24 h内累计排泄量为(3 044±1 336)ng。结论:盐酸阿比朵尔在大鼠体内分布迅速且广泛,主要以代谢产物形式排出体外。Objective： To investigate the distribution and excretion of arbidol hydrochloride in rats. Meth- ods： After a single oral dose of arbidol hydrochloride 54 mg.kg-1 was taken, the biological samples were collected from the rats, including feces, urine, bile and the tissue samples. The drug concentrations in the samples were de- termined by a developed LC/MS method. Results： The drug was detectable 5 min after administration. Besides di- gestive tract, high drug concentrations were detected in lung, liver and spleen, which was quite helpful for arbidol to show its biological efficacy. The cumulative amount of arbidol was （2 018 ± 578） μg in feces within 72 h after administration, and was only （2 858 ± 1 744） ng in urine. The excretion of arbidol from bile was slight and con- stant, with the cumulative amount of （3 044 ±1 336） ng within 24 h after dosing. Conclusion： The distribution of arbidol hydrochloride in rats is rapid and wide. Most of the administrated drug is excreted in metabolized forms.

关 键 词：盐酸阿比朵尔 组织分布 排泄 液相色谱-串联质谱法 大鼠 

分 类 号：R969.1[医药卫生—药理学]