PPARγ2基因多态性与哈萨克族代谢综合征关系  

Association of Pro12Ala and C1431T polymorphisms of PPARγ2 gene with metabolic syndrome in Xinjiang Kazakh

作　　者：齐春娜[1] 郭淑霞[1] 马儒林[1] 郭恒[1] 丁玉松[1] 张景玉[1] 徐上知[1] 孙凤[1] 

机构地区：[1]新疆石河子大学医学院预防医学系,新疆石河子832002

出　　处：《中国公共卫生》2013年第4期493-495,共3页Chinese Journal of Public Health

基　　金：国家"十一五"科技支撑计划(2009BAI82B04);新疆生产建设兵团国际科技合作项目(2009YD33)

摘　　要：目的探讨PPARγ2基因Pro12Ala、C1431T多态性与哈萨克族代谢综合征(MS)关系。方法应用基质辅助激光解析电离时间飞行质谱技术检测245例MS患者和244名对照者PPARγ2基因Pro12Ala、C1431T的基因型。结果与对照组比较,MS组Pro12Ala位点PP基因型和P等位基因频率差异均无统计学意义(P>0.05);MS组C1431T位点CC基因型和C等位基因频率分别为78.8%和87.6%,均高于对照组的68.4%、83.0%(P<0.05);多因素logistic回归分析显示,C1431T位点CC基因型是MS的危险因素(OR=2.043);不同因素间交互作用结果显示,饮酒者携带C1431T位点CC基因型是不饮酒者携带CT/TT基因型患病风险的2.788倍。结论 PPARγ2基因C1431T位点CC基因型、C等位基因可能是MS的遗传危险因素,CC基因型与饮酒可能存在相加交互作用。Objective To investigate the association of peroxisome proliferator activated receptor（PPAR） r2 gene Prol2Ala and C1431T polymorphisms with metabolic syndrome. Methods Matrix assisted laser desorption/ionization time-of-flight mass spectrometry（MALDI-TOF-MS） was used to detect PPARr2 gene Prol2Ala and C1431T genotypes in 489 subjects（245 metabolic syndrome patients and 244 controls）. Results The frequencies of Prol2Ala genotype （X2 = 0.050 ,P = 0.822） and allele（x2 = 0.108, P = 0.742） showed no significant differences between the patients and the controls. The frequencies of C1431T CC genotype and C allele for metabolic syndrome patients were all higher than those of the controls （CC genotype：78.8 % vs 68.4%, P = 0.01; C allele：87.6 % vs 83.0%, P = 0.044）. Multiple logistic regression analyses suggested that risk factor for metabolic syndrome was CC genotype（ OR = 2.043）. The results of interaction analyses for different factors indicated that the risk for metabolic syndrome in alcohol drinkers with CC genotype was 2.788 times of that non-drinkers with CT/TT genotype. Condusion The PPARr2 gene C1431T polymorphism is associated with metabolic syndrome risk in Kazakh. CC genotype and C allele may serve as genetic risk factors of metabolic syndrome and CC genotype and alcohol drinking may have additive effect on metabolic syndrome.

关 键 词：哈萨克族 代谢综合征(MS) PPARΓ2基因 基因多态性 

分 类 号：R589[医药卫生—内分泌]