响应面法优化超临界CO_2萃取丁香酚的工艺研究  

Optimization of supercritical CO_2 extraction of eugenol from clove(Eugenia caryophyllataThunb) bud by response surface methodology

作　　者：谢莹莹[1] 王志祥[1] 史益强[1] 丁朝中[1] 

机构地区：[1]中国药科大学药学院,南京210009

出　　处：《西北药学杂志》2013年第2期122-125,共4页Northwest Pharmaceutical Journal

摘　　要：目的优选丁香中丁香酚的超临界CO2萃取工艺。方法以丁香酚得率为考察指标,在单因素实验的基础上,采用响应面法对超临界CO2萃取丁香酚的工艺条件进行优化。结果得到优选萃取条件为:萃取压力25MPa,萃取温度55℃,萃取时间1h,夹带剂体积分数90%乙醇,夹带剂流量0.04mL.min-1,原料粒径100目,在此条件下丁香酚得率可达到17.41%。结论优选的萃取工艺稳定、可行。Objective To optimize the supercritical CO2 extraction process of eugenol from colve（Eugenia caryophyllata Thunb）.Method On the basis of single factors,using extraction rate as reference,extraction conditions of eugenol from clove（Eugenia caryophyllata Thunb） bud with supercritical CO2 extraction was optimized with response surface analysis.Results The optimum extraction conditions were as follows：power 25 MPa,temperature 55 ℃,time 1 h,volume fraction of alcohol 90%,and flow of modifier 0.04 mL·min-1,particle size 100 mesh.Under these conditions eugenol extraction rate could reach to 17.41%.Conclusion The optimized process conditions are stable and practicable in manufacture.

关 键 词：丁香 丁香酚 超临界CO2萃取 响应面法 

分 类 号：R284.2[医药卫生—中药学]