成都地区婴幼儿腹泻标本分离菌株的耐药性研究  

Study on the bacterial resistance of infantile diarrhea samples in Chengdu

作　　者：曹霞[1] 周涛[1] 杜晓昕[1] 鲁蕾[1] 范雪佳[1] 裴晓方[1,2] 

机构地区：[1]四川大学华西公共卫生学院(华西第四院),四川成都610041 [2]食品安全监测与风险评估四川省重点实验室

出　　处：《现代预防医学》2013年第8期1472-1474,共3页Modern Preventive Medicine

基　　金：国家科技重大专项"传染病检测技术平台"项目;"云南省周边省市传染病病原谱流行规律研究"课题(2009ZX10004-212)

摘　　要：目的比对分析成都地区婴幼儿腹泻标本分离菌中致病菌和普通大肠埃希菌对常用抗生素的耐药情况。方法采用K-B药敏纸片扩散法,分别对从400例腹泻患儿粪便中分离到的21株致病菌和255株普通大肠埃希菌进行药敏实验。结果普通大肠埃希菌和腹泻致病菌对常用抗生素出现了不同程度的耐药,普通大肠埃希菌对用抗生素的耐药性普遍高于腹泻致病菌,但两者对美罗培南、亚胺培南均敏感。结论药敏结果提示在应用抗生素时除了对致病菌耐药性的监测外,有必要加强对肠道正常菌群大肠埃希菌耐药的监测,合理使用抗生素,防止耐药质粒向致病菌传播。OBJECTIVE To investigate the antimicrobial resistance of pathogens and Escherichia coli which were isolated from patients with infantile diarrhea. METHODS 21 pathogens and 255 Escherichia coli bacteria were isolated from 400 cases with infantile diarrhea and analyzed, and K-B disc diffusion test was used to study the bacterial resistance. RESULTS The resistance of Escherichia coli was higher than that of pathogens. The isolated bacteria were highly sensitive to meropenem and imipenem （both 100% ）. CONCLUSION The experimental results suggest that we should strengthen the monitoring of Escherichia coli resistance in the application of antibiotics. With the rational use of antibiotics, we may prevent the spread of resistant plasmids to pathogens.

关 键 词：腹泻 细菌 耐药性 

分 类 号：R723.11[医药卫生—儿科]