Temperature-dependent THz vibrational spectra of clenbuterol hydrochloride  

作　　者：YANG YuPing LEI XiangYun YUE Ai ZHANG ZhenWei 

机构地区：[1]School of Science, Minzu University of China [2]Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Key Laboratory of Terahertz Optoelectronics (Ministry of Education), Department of Physics, Capital Normal University

出　　处：《Science China(Physics,Mechanics & Astronomy)》2013年第4期713-717,共5页中国科学：物理学、力学、天文学（英文版）

基　　金：partly supported by the Fundamental Research Funds for the Central Universities;the National Natural Science Foundation of China (Grant Nos. 11104360 and11204191);Project 985 (Grant no. 98507-010009);Project 211 of the Ministry of Education of China;the Under graduate Innoviative Test Program funded by Minzu University of China (Grant No. URTP2012-110005)

摘　　要：Using the high-resolution Terahertz Time-domain spectroscopy (THz-TDS) and the standard sample pellet technique, the far-infrared vibrational spectra of clenbuterol hydrochloride (CH), a 2 -adrenergic agonist for decreasing fat deposition and enhancing protein accretion, were measured in temperature range of 77-295 K. Between 0.2 and 3.6 THz (6.6-120.0 cm-1 ), seven highly resolved spectral features, strong line-narrowing and a frequency blue-shift were observed with cooling. However, ractopamine hydrochloride, with some structural and pharmacological similarities to clenbuterol hydrochloride, showed no spectral features, indicating high sensitivity and strong specificity of THz-TDS. These results could be used for the rapid and nondestructive CH residual detection in food safety control.Using the high-resolution Terahertz Time-domain spectroscopy （THz-TDS） and the standard sample pellet technique, the far-infrared vibrational spectra of clenbuterol hydrochloride （CH）, a 2 -adrenergic agonist for decreasing fat deposition and enhancing protein accretion, were measured in temperature range of 77–295 K. Between 0.2 and 3.6 THz （6.6–120.0 cm–1 ）, seven highly resolved spectral features, strong line-narrowing and a frequency blue-shift were observed with cooling. However, ractopamine hydrochloride, with some structural and pharmacological similarities to clenbuterol hydrochloride, showed no spectral features, indicating high sensitivity and strong specificity of THz-TDS. These results could be used for the rapid and nondestructive CH residual detection in food safety control.

关 键 词：Terahertz Time-domain spectroscopy clenbuterol hydrochloride ractopamine hydrochloride 

分 类 号：TN21[电子电信—物理电子学]