IVF/ICSI临床妊娠后流产的相关因素分析  

A study of related factors of miscarriage in IVF/ICSI.

作　　者：李兰英[1] 张瑞[1] 周燕[1] 刘静[1] 王一青[1] 张学红[1] 

机构地区：[1]兰州大学第一医院生殖医学专科医院,兰州730000

出　　处：《中国优生与遗传杂志》2013年第3期108-110,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨不孕症患者接受体外受精/卵细胞浆内单精子注射(IVF/ICSI)胚胎移植治疗临床妊娠后发生流产的可能相关因素。方法将2010年1月—2010年12月在本医院行IVF/ICSI治疗获得临床妊娠的512例患者,按妊娠结局分为流产组及分娩组;分析受精方式、年龄、病因及移植后12天血β-HCG等因素与流产率的关系。结果行IVF/ICSI助孕临床妊娠的患者中,流产率19.34%,抱婴儿回家率37.31%;行IVF与ICSI不同受精方式助孕的患者,其流产率、分娩率、抱婴儿回家率之间差异无统计学意义(P>0.05);流产组患者的年龄、胚胎种植率、多胎妊娠率及12天后的血β-HCG值均要低于分娩组,差异有统计学意义(P<0.05)。结论年龄及血β-HCG可早期预测IVF/ICSI的妊娠结局,对流产高风险患者及时进行保胎治疗,督促复诊,将有助于提高IVF/ICSI助孕后的活产率。Objective： To explore the related factors of miscarriage after clinical pregnancy in in vitro fertilization and intracytoplasmic sperminjection（IVF/ICSI）.Methods： A total of 512 gestational cycles of IVF/ICSI conducted between January 2010 and December 2010 were divided into two groups： miscarriage group and control group,Analysis the rate of the relationship in fertilization methods,age,the cause of infertility and β-HCG after 12 days.Results： Take baby home rate was 37.31% of total 1124 cases,and the miscarriage rate was 19.34% of clinical pregnancy woman.The miscarriage rate and take baby home rate in the IVF group were lower than ICSI group.The average age of the women,implantation rate,multiple pregnancy rate and the level of β-HCG in the miscarriage group were lower than the control group（P0.05）.Conclusion： Age and β-HCG can be used as risk factors of early prediction the occurrence of miscarriage in IVF/ICSI,taking necessary treatments in early phase of miscarriage may reduce risk occurrence probability.

关 键 词：体外受精-胚胎移植技术 胞浆内单精子注射技术 流产 相关因素 

分 类 号：R714.8[医药卫生—妇产科学]