丙酸倍氯米松鼻喷雾剂合依匹斯汀治疗变应性鼻炎临床研究  

Clinical Study on Allergic Rhinitis Treated by Beclometasone Dipropionate Nasal Spray with Epinastine

作　　者：范海生[1] 张淑君[1] 梁顺美 

机构地区：[1]广东省佛山市南海区第二人民医院,佛山528251

出　　处：《实用中西医结合临床》2013年第2期1-2,共2页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广东省佛山市卫生局科研基金(项目编号:2011294)

摘　　要：目的:评价丙酸倍氯米松鼻喷雾剂联合依匹斯汀治疗变应性鼻炎(allergic rhinitis,AR)的临床疗效。方法:159例AR患者采用随机、对照方法,治疗组80例,用丙酸倍氯米松鼻喷雾剂喷鼻,2次/d,每次各鼻孔2揿,依匹斯汀片口服,1次/d,每次10mg;对照组79例,用丙酸倍氯米松鼻喷雾剂喷鼻,2次/d,每次各鼻孔2揿;疗程均为4周。分析比较治疗前、后各项观察指标。结果:治疗1个疗程后,大部分患者临床表现均有明显改善;治疗组总有效率为92.5%,对照组为73.4%。两组治疗前后临床表现比较有统计学意义(P<0.05),两组总有效率比较差异有统计学意义(P<0.05)。结论:丙酸倍氯米松鼻喷雾剂联合依匹斯汀应用见效快,效果好,能有效缓解AR患者鼻部症状,值得推广。Objective：To evaluate the efficacy of beclometasone dipropionate nasal spray with epinastine treating allergic rhinitis（AR）.Methods：159 Cases with AR were randomly divided into two groups,treatment group（80 cases）and control group（79 cases）.In the treatment group,patients received beclometasone dipropionate nasal spray twice a day,two sprays in each nostril,and then take epinastine orally once a day with a dosage of 10 mg.In the control group,the patients received beclometasone dipropionate nasal spray twice a day,two sprays in each nostril.The course was 4 weeks.The efficacy of both groups were analyzed.Results：After one course of treatment,the clinical manifestations on most patients were significantly improved,with total effective rates of 92.5% and 73.4% in the treatment group and control group respectively.There was statistic significance on clinical manifestations before and after treatment between the two groups（P 0.05）,while significant difference on total effective rates between the two groups（P 0.05）.Conclusion：The combimation of beclometasone dipropionate nasal spray with epinastine is quick with good effects for local application,which can effectively relievelocal symptoms for patients with AR.

关 键 词：丙酸倍氯米松鼻喷雾剂 依匹斯汀 变应性鼻炎 治疗 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]