褐藻氨酸降压机制的在体受体分析  

ANALYSIS OF RECEPTORS FOR LAMININE HYPOTENSIVE EFFECT

作　　者：安建强[1] 孙世锡[1] 

机构地区：[1]青岛大学医学院药理学教研室,青岛266021

出　　处：《青岛大学医学院学报》2000年第4期256-258,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：1目的　探讨褐藻氨酸 (L A)降压的作用机制。 2方法　将整体动物 (犬、猫、大鼠 )经静脉或中枢给予 L A ,观察用药后动脉血压和瞬膜的反应。 3结果　 L A中枢与静脉给药降压作用差异无显著性 (t=2 .0 2 4,P>0 .0 5 )。L A的降压作用与血管运动中枢的 Bezold- Jarisch反射无关 ,与肾上腺素α,β受体、N1 胆碱受体及 H1 组胺受体亦无关 ,但硫酸阿托品能拮抗 L A的降压作用 ,差异有极显著性 (t=3.2 6 4,P<0 .0 1)。 4结论　 L A具有激动 M胆碱受体作用。Objective To study the hypotensive mechanism of Laminine(LA).\ Methods\ The intact animals (dog,cat and rat) were administered LA intravenously or through vertebral artery. The effects of the arterial blood pressure and the nictitating membrane action were observed.\ Results\ The hypotensive action of LA was not different in the two ways of administration ( t=2.024,P >0.05). The hypotensive effect of LA was neither related to the reflection of Bezold Jarisch, nor to α,β,N 1,H 1 receptors. Atropine sulphas could significantly antagonize the hypotensive effect of LA.\ Conclusion\ The LA might be a M receptor agonist. [

关 键 词：褐藻氨酸 中枢神经系统 神经节 受体 胆碱能 

分 类 号：R961[医药卫生—药理学]