口服米索前列醇用于胎膜早破产妇的引产  

Oralling misoprostolon the induction of labor of premature rupture of fetal membranes parturient

作　　者：庄桂霞[1] 苏绮枫[1] 程利南[1] 

机构地区：[1]中国福利会国际和平妇幼保健院,200030

出　　处：《中国妇幼保健》2000年第9期550-552,共3页Maternal and Child Health Care of China

摘　　要：目的　探讨口服米索前列醇混悬液用于足月妊娠胎膜早破产妇引产的有效性和安全性。方法　 12 0例孕足月胎膜早破的初产妇 ,分为两组。A组 6 0例口服米索混悬液 (2 0 0 μg/ 2 0 0 ml) ,每 2 h1次 ,初起每次 2 0 ml,连续 3次后若无规律宫缩出现 ,第 4次起改为每次 40 ml,若出现有效宫缩即停药 ,否则直至服完 2 0 0 ml。B组 6 0例静滴催产素作对照。结果　 A组引产成功率 96 .7% ,高于 B组的 85 .0 % (P<0 .0 5 )。A组从首次用药至临产及阴道分娩的平均时间较B组明显缩短 (P<0 .0 5 )。A组剖宫产率较 B组显著降低 (P<0 .0 1)。两组产后 2 h出血量及羊水污染、胎儿窘迫、新生儿窒息的发生率间差异均无显著性。口服米索混悬液用于足月妊娠胎膜早破产妇引产是一种安全、有效、方便的方法 。Objective:Probe into the effective and safe quality of oralling misoprostol suspention on the induction of labor of full term pregnant premature rupture of fetal membranes parturient. Methods: 120 full term pregnant rupture of fetal membranes parturient were divided into two groups: A group was 60 cases, oralling misoprostol suspention(200 μg/200 ml), 1 time/2 h, frist was 20 ml/time, after 3 times, if no regular uterine contraction, from the 4th time changed to 40 ml/time, if had effective uterine contraction, then stop, Otherwise till to oral 200 ml completely. B group was 60 cases, i.v.d oxytocic as control.Results: The successful rate of A group was 96.7%, was higher than 85.0% of B group (P<0 05) . The mean times of A group from oralling medicine to parturient and vagina delivery shorten evidently than B group (P<0 05) ,hysterotokotomy rate of A group decreased evidently than B group (P<0 01) . The amount of bleeding after 2 h and the rate of amniotic fluid pollution, fetal distress, asphyxia neonatorum between A and B group had no differency evidently. Oralling misoprostol suspention on the induction of labor of full term pregnant premature rupture of fetal membranes parturient was a safe, effective, instant way, its effect was better than oxytocic.

关 键 词：米索前列醇 胎膜早破 药物引产 

分 类 号：R714.433[医药卫生—妇产科学] R719.31[医药卫生—临床医学]