银杏内酯A、B和白果内酯的分离与纯化  

Isolation and Purification of Ginkgolide A, B and Bilobalide

作　　者：韩金玉[1] 褚巧伟[2] 常贺英[2] 王华[2] 王海静 

机构地区：[1]天津大学化工学院有机合成与高分子化工系 [2]天津大学化工学院,300072

出　　处：《中草药》2000年第9期652-653,共2页Chinese Traditional and Herbal Drugs

基　　金：天津市自然科学基金项目!(No.9936 0 6 911)

摘　　要：以银杏叶浸膏 EGb76 1 为原料 ,通过预处理、制备色谱和重结晶过程 ,得到纯度达 98%以上的银杏内酯 A、B和白果内酯纯品。建立了一种较简单的分离和纯化银杏内酯 A。A simple method for the isolation and purification of ginkgolide A, B and bilobalide (ginkgo terpene trialctone) was developed A commercially available extract of leaves of Ginkgo biloba L. containing >6% ginkgo terpene trilactone was used as the raw material After partition in EtOAc, the enriched extract was separated to give individual terpenes by preparative liquid chromatography Ginkgolide A, B and bilobalide could be isolated with high purity by recrystallizing in MeOH H 2O

关 键 词：银杏内酯 白果内酯 制备色谱 预处理 重结晶 

分 类 号：R284.2[医药卫生—中药学]