L-组氨酸催化水相合成5-芳亚甲基罗丹宁  

SYNTHESIS OF 5-ARYLIDENE RHODANINE CATALYZED BY L-HISTIDINE IN WATER

作　　者：刘慧强[1] 邱建华[1] 朱朝俞[1] 张兰[1] 杨小斌[1] 郭丽涛[1] 乐长高[1] 

机构地区：[1]东华理工大学化学生物与材料科学学院,江西抚州344000

出　　处：《精细石油化工》2013年第2期39-42,共4页Speciality Petrochemicals

基　　金：国家自然科学基金项目(No.21262002);江西省自然科学基金项目(No.2010GZH003);江西省科技厅优势科技创新团队计划项目(20113BCB24001);东华理工大学研究生创新基金项目(No.DYCA12004)

摘　　要：研究了水相中L-组氨酸催化芳香醛与罗丹宁的Knoevenagel缩合反应。实验中考察了催化剂用量、溶剂种类、芳香醛的种类等因素对反应的影响。结果表明:室温下的水中,L-组氨酸能有效催化芳香醛与罗丹宁的反应,该法具有产率高(83%～95%)、时间短(15～35min)、后处理简单等优点。Knoevenagel condensation with aromatic aldehydes and rhodanine catalyzed by L-Histidine in water was studied. The effects of different kinds of catalyst and aromatic aldehydes, catalyst dos- age, solvent type were investigated. The results showed that L-Histidine could effectively catalyze the reaction of aromatic aldehyde and rhodanine in aqueous phase at ambient temperature. This method have many advantages, such as high yield （83%-95%）, short reaction time （15-35 min）, simple post-processing and so on.

关 键 词：氨基酸 水相 KNOEVENAGEL缩合反应 

分 类 号：O621.3[理学—有机化学]