神经生长因子治疗新生儿缺氧缺血性脑病效果观察  

NEONATAL HYPOXIC ISCHEMIC ENCEPHALOPATHY TREATED WITH NERVE GROWTH FACTOR

作　　者：吴兴富 刘金生[2] 王召安[2] 王玉巧[2] 

机构地区：[1]临沂市卫生学校,山东省临沂市276002 [2]临沂市人民医院儿科

出　　处：《齐鲁医学杂志》2000年第3期181-182,共2页Medical Journal of Qilu

摘　　要：1目的　观察神经生长因子对新生儿缺氧缺血性脑病 (HIE)疗效。 2方法　将足月 HIE新生儿随机分为 A,B组 ,A组单用脑活素 ,B组用神经生长因子及脑活素治疗 ,并给予早期干预。生后 5 d内、发病后 18～ 2 5 d,90～ 180 d行头颅 CT平扫 ,发病后 18～ 2 5 d行新生儿行为神经测定 (NBNA) ,90～ 180 d行 Gesell发育量表检查。 3结果　 B组在头颅 CT恢复程度、NBNA测定、智力测定等方面明显优于 A组 (χ2 =5 .31～ 9.11,P<0 .0 5 ;t=6 .95 ,P<0 .0 1)。 4结论　神经生长因子对促进Objective\ To observe the therapeutic effect of nerve growth factor(NGF) on neonatal hypoxic ischemic encephalopathy(HIE).\ Methods\ One month or older newborns with HIE were randomly divided into group A and group B. The newborns in group A were treated with cerebrolysin only, those in group B were treated with the combination of NGF and cerebrolysin and early management was done. CT scan was done within five days of life, and 18-25 days and 90-180 days after the onset of the disease. And neonatal behavior neurological assessment(NBNA) was performed during 18-25 days after the onset of the disease. IQ values were determined by Gesell Development Level Chart.\ Results\ The newborns in group B showed notably better results than those in group A in terms of the degree of recovery shown by skull CT, NBNA determination, and intelligence determination.\ Conclusion\ NGF has notable effect in promoting recovery of the function of central nervous system. [

关 键 词：缺氧缺血性脑病 神经生长因子 新生儿 

分 类 号：R722.120.5[医药卫生—儿科]