利钾尿肽与心钠素摩尔比在老年原发性高血压中的作用  

Role of the molar ratio of kaliuretic peptide/atrial natriuretic peptide in elderly essential hypertension

作　　者：曾强[1] 陈练[1] 苑杰 鲁菁[1] 范英鲜[1] 余霞君[1] 

机构地区：[1]解放军总医院,南楼二科北京100853

出　　处：《中国病理生理杂志》2000年第9期775-778,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助课题 (批准号39970806);全军九五医药卫生科研基金资助课题!(编号98Q092)

摘　　要：目的 :探讨利钾尿肽 (KP)与心钠素摩尔比变化在老年原发性高血压发病中的意义。方法 :用放射免疫分析方法测定老年高血压患者血浆、老年自发性高血压大鼠 (SHR)血浆及心房和心室组织的KP和心钠素(ANP)含量。结果 :高血压患者血浆KP、ANP水平与对照组比较无显著差异。但是 ,KP与ANP的摩尔比显著低于对照组 (P <0 0 5 ) ,SHR血浆KP、ANP水平显著高于对照组 (WKY) (P <0 0 1和P <0 0 5 ) ,KP/ANP摩尔比则显著低于WKY(P <0 0 1)。SHR心房KP含量高于心室 (P <0 0 5 ) ,但与对照组WKY比较无显著差异。结论 :KP含量及KP与ANP的比例关系的改变 。AIM: To investigate the role of the molar ratio of kaliuretic peptide/atrial natriuretic peptide in elderly essential hypertension(EH). METHODS: The levels of plasma kaliuretic peptide (KP) and atrial natriuretic peptide (ANP) in 46 elderly patients with essential hypertension (EH) and 11 spontaneuos hypertension rats (SHR) were determined by radioimmunoassay. Meanwhile, the concentation of KP and ANP in myocardium of rats were observed as well. RESULTS: Compared with control group, the plasma levels of KP and ANP in EH group were no significantly different, but the molar ratio of KP/ANP were lowered significantly ( P<0.05 ). The levels of plasma KP and ANP in SHR were significantly higher than those in Wistar-Kyoto rats (WKY)( P<0.01 and P<0.05 respectively). However, the molar ratio of KP/ANP were markedly lower( P<0.01 ). The concentration of KP in atrium was significantly higher than that in ventricle in SHR( P<0.01 ). Moreover, there are no significantly different between SHR and SKY in atrium concentration of KP. CONCLUSION: KP and the molar ratio of KP/ANP maybe play an important role in pathogenesis of elderly essential hypertension.

关 键 词：高血压 心钠素 老年人 利钾尿肽 摩尔比 

分 类 号：R544.1[医药卫生—心血管疾病]