慢性咳嗽患者呼出气一氧化氮对气道高反应性的判定作用  

Evaluation of the Validity of Fractional Exhaled Nitric Oxide for Screening Airway Hyperresponsiveness in Patients with Chronic Cough

作　　者：牟艳[1] 龚颖[1] 叶伶[1] 安霞[2] 金美玲[1] 

机构地区：[1]复旦大学附属中山医院呼吸科,上海200032 [2]泰山医学院附属医院呼吸科,山东泰安271000

出　　处：《中国临床医学》2013年第1期29-30,共2页Chinese Journal of Clinical Medicine

基　　金：上海市重点学科建设项目资助(编号:B115);复旦大学新教师科研启动基金(编号:10FX088)

摘　　要：目的:探讨呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)检测用于判定慢性咳嗽患者的气道高反应性的可行性。方法:对73例慢性咳嗽患者行支气管激发试验及FeNO检测。结果:73例患者中,支气管激发试验阳性35例(阳性组),阴性38例(阴性组)。阳性组FeNO水平为(50.20±47.36)ppb,阴性组FeNO水平为(15.08±5.20)ppb,两组相比差异有统计学意义(P<0.05)。FeNO用于判定慢性咳嗽患者的气道高反应性时,受试者工作特征(receiver operating characteristic,ROC)曲线下面积为0.905,最佳阈值为22.5ppb,此时检验的敏感度为71.43%,特异度为97.37%,阳性预测值为96.15%,阴性预测值为78.72%。结论:FeNO检测可用于慢性咳嗽患者气道高反应性的判定,该指标有助于慢性咳嗽的鉴别诊断。Objective：To evaluate whether fractional exhaled nitric oxide（FeNO） can be used to screen airway hyperresponsiveness（AHR） in patients with chronic cough.Methods：A total of 73 patients with chronic cough had undergone bronchial provocation test and the test of FeNO level.Results： The results of bronchial provocation test were positive in 35 cases（positive group） and negative in 38 cases（negative group）.The FeNO level in the positive group [（50.20±47.36） ppb] was significantly higher than that in the negative group [（15.08±5.20） ppb],P0.05.The area under receiver operating characteristic（ROC） curve was 0.905;the optimal cutoff value of FeNO was 22.5ppb with sensitivity of 71.43%,specificity of 97.37%,positive predictive value of 96.15% and negative predictive value of 78.72%.Conclusion： FeNO level can be used to screen AHR with a high sensitivity and specificity,and thus it contributes to the differential diagnosis of chronic cough.

关 键 词：呼出气一氧化氮 支气管激发试验 气道高反应性 慢性咳嗽 

分 类 号：R441[医药卫生—诊断学]