头孢替安和左氧氟沙星联合序贯治疗中重度下呼吸道感染的疗效分析  

Efficacy of Cefotiam and Levofloxacin as a Sequential Therapy in the Treatment of Serious Respiratory Tract Infections

作　　者：施文权[1,2] 储德节[1] 孙书明[1] 

机构地区：[1]复旦大学附属金山医院呼吸内科,上海201508 [2]上海市金山区金山卫社区卫生服务中心

出　　处：《中国临床医学》2013年第1期34-35,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:评价头孢替安和左氧氟沙星联合序贯疗法治疗中重度下呼吸道感染的临床疗效。方法:2011年8月—2012年8月复旦大学附属金山医院呼吸内科共收治133例中重度下呼吸道感染患者。将所有患者随机分为对照组(n=67)和序贯组(n=66)。对照组给予头孢替安和左氧氟沙星氯化钠静脉滴注,疗程14d。序贯组先给予头孢替安和左氧氟沙星氯化钠静脉滴注,疗程7d;然后给予头孢呋辛酯和左氧氟沙星口服治疗,疗程7d。比较两组的疗效、细菌清除率、不良反应和治疗费用。结果:对照组、序贯组的有效率分别为91.0%和90.5%(P>0.05);不良反应发生率分别为5.97%和4.55%(P>0.05);细菌清除率分别为85.7%和85.4%(P>0.05);对照组平均抗生素应用费用人民币1525.44元,序贯组平均抗生素应用费用人民币844.71元(P<0.01)。结论:头孢替安和左氧氟沙星联合序贯疗法治疗中重度下呼吸道感染的疗效确切,且可节约治疗费用,值得在社区基层医院推广。Objective：To evaluate the efficacy of cefotiam and levofloxacin as a sequential therapy in the treatment of serious respiratory tract infections.Methods：A total of 133 patients with serious respiratory tract infections hospitalized in Jinshan Hospital,Fudan University from August 2011 to August 2012 were enrolled and randomly assigned into 2 groups.Sixty-seven patients in the control group were treated with cefotiam and levofloxacin via intravenous infusion for 14 days.Sixty-six patients in the sequential group were treated with cefotiam and levofloxacin via intravenous infusion for 7 days,and then they were treated with cefuroxime axetil and levofloxacin orally for another 7 days.The clinical effects,bacterial clearance rate,adverse reactions and costs in both groups were observed and compared.Results： The effective rate,adverse reaction rate,and bacterial clearance rate were 91.0%,5.97% and 85.7% in the control group,respectively;they were 90.5%,4.55% and 85.4% in the sequential group,with no significant differences between the two groups（all P0.05）.However,the expenses between the two groups had statistical significance（P0.01）.The average cost of antibiotics in the control group was 1525.44 Yuan,while that in the sequential group was 844.71Yuan（P0.01）.Conclusions： The sequential therapy is an effective way to treat serious respiratory tract infections with lower costs,and thus it can be applied in the community hospitals.

关 键 词：联合序贯疗法 头孢替安 左氧氟沙星 呼吸道感染 

分 类 号：R56[医药卫生—呼吸系统]