CD64指数在早产儿细菌感染中的早期诊断价值  

The Value of Neutrophil CD64 Index in the Early Diagnosis of Bacterial Infection in Premature Infants

作　　者：龚敬宇[1] 张梅虹[1] 濮泽琼[1] 丁柳美[1] 郭建新[1] 

机构地区：[1]复旦大学附属金山医院儿科,上海201508

出　　处：《中国临床医学》2013年第1期49-50,共2页Chinese Journal of Clinical Medicine

基　　金：上海市金山区卫生局资助项目(编号:2009-18)

摘　　要：目的:探讨中性粒细胞表面CD64指数在早产儿细菌感染中的早期诊断价值。方法:将100例早产儿根据出院诊断分为细菌感染组(n=56)和非细菌感染组(n=44),入院24h内测定血常规、CD64指数及C反应蛋白(C-reactive protein,CRP)等指标,同时作血培养、痰培养等病原学检查。比较两组CD64指数及其他各项指标。根据受试者工作特征(receiver opera-ting characteristic,ROC)曲线确定CD64指数的最佳临界值。结果:细菌感染组与非细菌感染组CD64指数分别为12.1±6.3和6.9±1.9,两组早产儿CD64指数比较差异有统计学意义。细菌感染组CRP≥8mg/L者2例,非细菌感染组0例。细菌感染组早产儿白细胞计数与非细菌感染组比较差异无统计学意义。绘制ROC曲线,CD64指数曲线下面积为0.914,根据ROC曲线CD64指数取6.95为临界值,诊断早产儿感染的灵敏度、特异度、阴性预测值、阳性预测值、约登指数分别为89.3%、90.9%、2.6%、86.9%、76.2%。结论:中性粒细胞表面CD64对早产儿细菌感染的诊断价值较高。Objective：To evaluate the early diagnostic value of CD64 index on neutrophils for bacterial infection in premature infants.Methods：A total of 100 premature infants were enrolled in this study.They were classified into bacterial infection group（n=56） and non-infection group（n=44） according to the final diagnosis.The CD64 index was detected by flow cytometry.Blood culture of bacteria,the detection of C-reactive protein（CRP） and count of white blood cells have also been done.The CD64 index,CRP and count of white blood cells were compared between the two groups.According to the receiver operating characteristic（ROC） curve,the best cutoff value of CD64 index was calculated.Results： CD64 index in the bacterial infection group（12.1±6.3） was significantly higher than that in the non-infection group（6.9±1.9）,P0.01.There were 2 and 0 infants whose CRP were more than 8 mg/L in bacterial infection group and non-infection group,respectively.There was no significant difference in count of white blood cells between the two groups.The area under curve（AUC） was 0.914.Taking 6.95 as the cutoff value of CD64 index,the sensitivity,specificity,positive and negative predictive value and Youden＇s index of CD64 index in the diagnosis of bacterial infection in premature infants were 89.3 %,90.9 %,92.6%,86.9%,76.2% respectively.Conclusions： CD64 index is of great value for the early diagnosis of bacterial infection.

关 键 词：早产儿 感染 细菌 CD64指数 

分 类 号：R72[医药卫生—儿科]