抑郁认知易感者在负性情绪信息加工中的脑功能连接特征  

The characteristics of the functional connectivity in subjects with cognitive vulnerability to depressionwhile processing negative information

作　　者：蚁金瑶[1] 钟明天[2] 朱熊兆[1] 王湘[1] 廖坚[3] 姚树桥[1] 

机构地区：[1]中南大学湘雅二医院医学心理研究所,长沙410011 [2]华南师范大学心理应用研究中心 [3]中南大学湘雅三医院放射科

出　　处：《中华精神科杂志》2013年第2期71-77,共7页Chinese Journal of Psychiatry

基　　金：国家自然科学基金（81071104,81000590）;高等学校博士学科点专项科研基金新教师基金（200805331003）

摘　　要：目的探讨抑郁认知易感者和抑郁症患者在负性情绪信息加工过程中杏仁核与不同脑区之间是否具有特殊的脑功能连接方式。方法使用认知方式问卷筛查得到抑郁认知易感者（易感组，26例）与非易感者（对照组．31名），选取同期临床抑郁症患者（抑郁症组，29例），分别完成情绪面孔匹配任务，同步进行功能磁共振扫描；采用功能连接方法比较各组杏仁核与不同脑区之间的功能连接差异。结果易感组的杏仁核与右侧额中回之间的功能连接比对照组弱[蒙特利尔神经研究所（MNI）：26，40，-12；t=3．88，P〈0．001，％=10]，抑郁症组杏仁核与左侧额下回之间的功能连接比对照组弱（MNI：-46，24，-12；t=4．20，P〈0．001，k=16）。结论在面对负性刺激时，抑郁认知易感者和抑郁症患者杏仁核与前额叶之间的功能连接降低。Objective To examine the patterns of the functional connectivity between the amygdala and other brain regions in subjects with cognitive vulnerability and subjects with major depressive disorder while processing negative information. Methods Using the cognitive style questionnaire （CSQ） and some psychological scales, subjects with cognitive vulnerability （CV, 26 subjects） and healthy control subjects （HC, 31 subjects） were recruited. Besides, first-episode treatment-free subjects with major depressive disorder （MDD, 29 subjects） from outpatients in the psychology clinic were included. All subjects were scanned by functional magnetic resonance imaging （fMRI） while performing an emotional matching task. The functional connectivity patterns between the amygdala and other brain regions were examined for each group. Results The right middle frontal gyrus showed less connectivity with the amygdala in subjects with CV than in HC subjects [ Montreal Neurological Institute （MNI） ： 26, 40, - 12 ; t = 3.88, P 〈 0. 001,k = 10]. The left inferior frontal gyms showed decreased connectivity with amygdala in MDD patients compared with HC subjects （MNI： -46, 24, - 12; t =4.20,P 〈0. 001 ,k = 16）. Conclusion When viewing negative stimuli, the functional connectivity between the amygdala and the prefrontal cortex is decreased in individuals with CV and MDD.

关 键 词：抑郁症 磁共振成像 杏仁核 负性认知加工 脑功能连接 认知易感者 

分 类 号：R445.2[医药卫生—影像医学与核医学]