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作 者:黎民君[1] 郭丽堃[1] 陈利媚[1] 冯思琼[1]
机构地区:[1]广东省梅州市人民医院血液内科,广东梅州514000
出 处:《中国现代医生》2013年第7期40-41,共2页China Modern Doctor
摘 要:目的对急性白血病(ALL)患者CD4+CD25+调节性T细胞变化进行研究。方法 26例化疗后完全缓解的ALL患者为完全缓解组,20例初次治疗的急性淋巴细胞白血病患者为初治组,另选择20例健康志愿者为对照组,检测各组调节性T细胞的变化。结果完全缓解组和对照组外周血CD4+CD25+调节性T细胞水平明显低于初治组,差异有统计学意义(P<0.05)。完全缓解组与对照组比较,无统计学差异(P>0.05)。结论急性淋巴细胞白血病患者的CD4+CD25+调节性T细胞检测具有一定的临床意义,为白血病的诊断和治疗提供了依据。Objective To study the change of CD4+CD25+regulatory T cells in patients with acute lymphoblastic leukemia(ALL). Methods A total of 26 patients with complete remission after chemotherapy were studied as complete remission group,20 patients with initial treatment were as initial treatment group,and the other 20 healthy volunteers were as control group,the change of regulatory T cells in each group was detected. Results CD4+CD25+ regulatory T cells levels in the complete remission group and control group were significantly lower than that in the initial treatment group,there were statistically significant (P 〈 0.05).About theCD4+CD25+ regulatory T cells level in the complete re- mission group and the control group,there was not significant (P 〉 0.05). Condusion There is certain clinical signifi- cance about CD4+CD25+ regulatory T cells level in the patients with acute lymphoblastic leukemia.h provides a basis for the diagnosis and treatment of leukemia.
关 键 词:CD4+CD25+调节性T细胞 急性淋巴细胞白血病 细胞免疫 肿瘤细胞
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