^(131)I治疗Graves病合并肝功能损害83例近期疗效观察  

Short-term effect of ^(131)I treatment in Graves patients with hepatic dysfunction

作　　者：许泽清[1] 贾晓娟[1] 唐彩华[1] 

机构地区：[1]中山大学第五附属医院,518000

出　　处：《实用医技杂志》2013年第4期373-374,共2页Journal of Practical Medical Techniques

摘　　要：目的观察131I治疗Graves病合并肝功能损害的疗效及安全性。方法在护肝治疗的基础上,对83例Graves病合并肝功能损害患者进行131I治疗,观察治疗前、治疗后2周和1、3、6个月的肝功能变化及治疗后6个月的疗效。结果131I治疗2周及1个月肝功能与治疗前比较差异无统计学意义(P>0.05),131I治疗3个月及6个月后肝功能与治疗前比较差异有统计学意义(P<0.01),治疗3个月及6个月肝功能逐渐恢复正常,其中治疗3个月后83例患者中肝功能恢复正常者45例,6个月后恢复正常者76例,占92%。131I一次治疗痊愈率57%,总有效率为99%,甲状腺功能减退症发生率19%。结论131I治疗Graves病合并肝功能损害安全有效,辐射不加重肝功能损害,随着131I治疗疗效的出现,肝损害逐渐恢复正常。Objective To evaluate the short-term efficacy of 131I treatment in Graves patients with hepatic dy s function.Methods A total of 83 Graves patients with hepatic dysfunction were given 131I therapy,the changes of hepatic functions（ALT,AST,ALP,A/G）and thyroid hormone（FT3,FT4） were determined before treatment,after treatment 2 weeks,1 month,3 months,6 months.Results Compared with before treatment,the hepatic functions（ALT,AST,ALP,A/G） after treatment 2 weeks,1 month was no significantly change（P0.05）,but the hepatic functions（ALT,AST,ALP,A/G） after treatment 3 months,6 months was significantly decreased（P0.01）.Among 83 Graves patients with hepatic dysfunction,45 patient′s hepatic functions were normal after 131I treatment for 3 months,76 patient′s hepatic functions were normal after 131I treatment for 6 months,the function of thyroid was recovered in 47 cases（57%）,improved in 19 cases（23%）,decreased in 16 cases（19%） and ineffective in 1 cases（1%） after 131I treatment for 6 months.Conclusion 131I treatment is highly effective and safe for Graves patients with hepatic dysfunction.

关 键 词：碘放射性同位素 格雷夫斯病 肝功能不全 

分 类 号：R581.1[医药卫生—内分泌]