老年非杓型高血压患者血压昼夜节律变化与尿微量白蛋白、同型半胱氨酸的相关性  

Relationship between day-night rhythm and urinary microalbumin,homocysteine in elderly patients with non-dipper essential hypertension

作　　者：单海燕[1] 李效娟 李婉[1] 祁慧萌[1] 王鹤智[1] 

机构地区：[1]中国医科大学第一附属医院,沈阳110001 [2]寿光市人民医院

出　　处：《山东医药》2013年第11期22-24,共3页Shandong Medical Journal

基　　金：辽宁省社会发展攻关计划课题项目(2012225091)

摘　　要：目的观察老年非杓型高血压患者血压昼夜节律变化与尿微量蛋白(MAU)、同型半胱氨酸(Hcy)的相关性。方法将110例老年高血压患者按照24 h动态血压(24 h ABPM)结果分为杓型组54例及非杓型组56例,分别检测MAU和Hcy水平。结果杓型组与非杓型组MAU水平分别为(12.46±2.69)、(22.09±3.18)mg/L,两组比较,P<0.01;Hcy水平分别为(15.97±1.58)、(19.35±2.01)μmol/L,两组比较,P<0.05。杓型组夜间收缩压(nSBP)与MAU、Hcy之间无相关性;非杓型组nSBP与MAU、Hcy之间存在正相关(r分别=0.285、0.538,P均<0.01)。结论老年非杓型高血压患者血压昼夜节律变化与MAU、Hcy关系密切。Objective To study the relationship between day-night rhythm and urinary microalbumin （ MAU）, plasma level of homocysteine （Hcy） in elderly patients with non-dipper essential hypertension （EH）. Methods According to the blood pressure-decreasing ratio in 24 hours ambulatory blood pressure monitor （24 h ABPM）, 110 elderly patients with EH were divided into dipper group （n = 54） and non-dipper group （n = 56）. MAU and Hcy in these patients were examined at the same time. Results The level of MAU in non-dipper group was significantly higher than that in dipper group [ （22.09 ± 3.18） mg/L vs （ 12.46 ± 2.69） mg/L, P 〈 0.01 ]. The plasma level of Hcy in non-dipper group was higher than that in dipper group[ （ 19.35 ± 2.01 ） μmol/L vs （ 15.97 ± 1.58 ） Ixmol/L, P 〈 0.05 ]. Linear correlation analysis showed that there was a positive relationship between nSBP and MAU, Hcy（ r = 0.285, P 〈 0. 01 ; r = 0.538, P 〈 0.01 ） in elderly patients with non-dipper essential hypertension. Conclusion Day-night rhythm in elderly patients with non-dipper EH is closely correlated with MAU and Hcy.

关 键 词：老年人 高血压 昼夜节律 尿微量白蛋白 同型半胱氨酸 

分 类 号：R544.1[医药卫生—心血管疾病]