恶性疟患者血清AST/ALT比值与溶血的相关性探讨  

Relationship of AST/ALT ratio and hemolysis in falciparum malaria patients

作　　者：张锁才[1] 邵幼林[1] 陈国春[1] 

机构地区：[1]常州市第三人民医院感染科,江苏常州213001

出　　处：《海南医学》2013年第8期1159-1161,共3页Hainan Medical Journal

摘　　要：目的探讨恶性疟患者血清AST/ALT比值特征及其与溶血的关系。方法测定40例在我院住院治疗的恶性疟患者和40例正常对照者血清天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、乳酸脱氢酶(LDH)、腺苷脱氨酶(ADA)、总胆红素(TBIL)和血常规,分析AST/ALT比值变化,采用简单回归分析和多元回归分析恶性疟患者AST/ALT比值与溶血的关系。结果恶性疟患者的AST、ALT、ADA、LDH、TBIL、Hb、PLT与正常对照者比较差异均有统计学意义。恶性疟患者AST/ALT为(1.59±0.89),正常对照者为(1.19±0.58),二者差异有统计学意义。AST/ALT比值与Hb呈负相关,与LDH呈正相关,与ADA、TBIL、PLT、性别、年龄等无关。结论恶性疟患者血清AST/ALT比值可作为溶血标志,对恶性疟诊断有重要提示意义。Objective To investigate the levels ofAST, ALT in falciparum malaria patients, and to explore the relationship of AST/ALT ratio and hemolysis. Methods The AST, ALT, ADA, LDH, TBIL, and blood routine of 40 falciparum malaria patients （the study group） and 40 healthy individuals （the control group） were investigated and analyzed retrospectively. Results The levels ofAST, ALT, ADA, LDH, TBIL, Hb, and PLT showed statistically sig- nificant difference between the study group and the control group. The AST/ALT ratio was （1.59±0.89） in the study group and （1.19±0.58） in the control group, with statistically significant difference between the two groups （P= 0.0249）. The AST/ALT ratio has a negative correlation with hemoglobin, but a positive correlation with lactate dehydrogenas. Conclusions The AST/ALT ratio serves as an indicator for hemolysis, which has great significance in the diagnosis of falciparum malaria.

关 键 词：恶性疟 天冬氨酸氨基转移酶 丙氨酸氨基转移酶 溶血 

分 类 号：R531.3[医药卫生—内科学]