针刺激活下丘脑室旁核促肾上腺皮质激素释放激素相关神经元特异性研究  

Study on Specificity of Acupoints in Acupuncture Activated Corticotrophin Releasing Hormone Relative Neurons in Paraventricular Area of Hypothalamus

作　　者：张娇娇[1,2] 王少军[1] 谭连红[1] 朱兵[1] 王朝晖[2] 

机构地区：[1]中国中医科学院针灸研究所,北京100700 [2]长春中医药大学针灸推拿学院,吉林长春130117

出　　处：《中国中医药信息杂志》2013年第4期34-37,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81072856)

摘　　要：目的观察针刺调节下丘脑-垂体-肾上腺皮质轴(HPA)功能的穴位特异性,并探讨针刺对HPA轴的调节是否具有累积效应。方法实验用SD雄性成年大鼠。胞外记录下丘脑室旁核促肾上腺皮质激素释放激素相关神经元电活动,比较针刺同一经脉不同神经节段、相同或相邻神经节段不同经脉的20个穴位对该神经元的激活效应及强度的差异,并观察不同针刺次数对不同时间点外周血皮质酮水平的影响。结果针刺20个穴位对该神经元的激活效应由大到小的顺序:肾俞>期门>肝俞>大椎>章门>腹哀>太乙>郄门>水沟>商曲>腹通谷>足三里>太冲>内关>京门>阳陵泉>承山>筑宾>三阴交>膻中。结论与肾上腺位于相同或相邻神经节段的膀胱经、肝经的穴位具有特异性效应,且有累积效应。Objective To observe the specificity of acupoints in regulation of hypothalamic pituitary adrenal（HPA） axis,and study the cumulative effect of acupuncture on HPA axis.Methods Experiments were performed on Sprague-Dawley male rats.Extracellular record the electric activities on corticotropin releasing hormone（CRH）-relative neurons in paraventricular area of hypothalamus,and compare the effects of 20 point acupuncture for same channel but different nerve segment,same or adjacent nerve segment but different channel.The changes of peripheral blood corticosterone level in different time and different acupuncture times were determined.Results The effects from large to small in 20 points was BL23LR14BL18GV14LR13SP16ST23PC4GV26KI17KI20ST36LR3PC6GB25 GB34BL57KI9SP6CV17.Conclusion The specificity of acupoints on effect of acupuncture regulation of HPA axis was bladder and liver channel points,which are in the same or adjacent nerve segment pertaining to the adrenal glands,and has cumulative effect.

关 键 词：针刺 下丘脑室旁核促肾上腺皮质激素释放激素相关神经元 特异性穴位 大鼠 

分 类 号：R242[医药卫生—中医临床基础]