口炎清颗粒提取和制粒工艺优选  

Optimization of Extraction and Granulation Process of Kouyanqing Granule

作　　者：江涛[1] 枉前[1] 邢茂[1] 樊丽[1] 张蓉[1] 

机构地区：[1]中国人民解放军第三军医大学新桥医院药剂科,重庆400037

出　　处：《中国中医药信息杂志》2013年第4期60-64,共5页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的优选口炎清颗粒的提取和制粒工艺。方法采用高效液相色谱法测定口炎清浸膏中芍药苷含量。以浸膏收率、芍药苷提取率为评价指标,用单因素试验和正交试验优化提取工艺。以吸湿率、堆密度、休止角为评价指标,采用多因素比较法和正交试验优化制粒工艺,并测定口炎清颗粒的临界相对湿度。结果最佳提取工艺为12倍60%乙醇回流提取3次,每次2 h。口炎清浸膏粉与糊精按6∶4比例混合后用90%乙醇制粒,制得的口炎清颗粒吸湿性小,流动性好,临界相对湿度约为63%。结论口炎清颗粒的提取和制粒工艺合理可行,稳定性好,可为工业化生产提供依据。Objective To optimize extraction and granulation process of Kouyanqing granule.Methods The content of paeoniflorin was determined by HPLC.Single-factor experiment and orthogonal test were used to optimize extraction process with extract yield and extraction ratio of paeoniflorin as evaluation indexes.Granulation process was studied by multi-factor comparison and orthogonal test,with moisture rate,bulk density and flowability as evaluation indexes.The critical relative humidity of granule was measured.Results The optimum extraction process was as follows：extracted 3 times with 12 folds 60% ethanol,and 2 h for each time.The optimum granulation process was as follows：prilled ratio of extractum and excipients was 6∶4,with 90% ethanol as wetting agent.The hygroscopicity of granule was less and flowability was well.The critical relative humidity of granule was about 63%.Conclusion The extraction and granulation process of Kouyanqing granule was reasonable and feasible,and provide basis for industrial production of Kouyanqing granule.

关 键 词：口炎清颗粒 高效液相色谱法 提取工艺 正交试验 制粒工艺 

分 类 号：R283.5[医药卫生—中药学]