高血压病及高血压心脏病患者血浆中ox-LDL的改变  

The Changes between the Plasma Concentration of Oxidized Low-Density Lipoprotein Level in Patients with Hypertension and Hypertensive Heart Disease

作　　者：刘颖[1] 宫海滨 

机构地区：[1]江苏省徐州市中心医院中心实验室,221009 [2]徐州市心血管病研究所心内科

出　　处：《中华全科医学》2013年第4期506-507,共2页Chinese Journal of General Practice

基　　金：江苏省生命健康科技专项资金资助(BL2012019);国家自然科学基金资助项目(30572073);江苏省自然科学基金项目(BK2005428);江苏省医学重点人才(RC2007024);徐州市科技发展项目(XZZD1018)

摘　　要：目的评估高血压病、高血压心脏病患者血浆中氧化型低密度脂蛋白(ox-LDL)的变化,探讨高血压病与氧化型低密度脂蛋白之间的关系。方法选择2009年10月-2010年5月徐州市中心医院门诊或心内科住院部原发性高血压患者30例和高血压心脏病患者31例,对照组为同期体检中心健康志愿者30例。采用酶联免疫吸附法(ELISA)测定血浆中ox-LDL的含量。结果与对照组相比,原发性高血压组和高血压心脏病组患者血浆中ox-LDL含量均增高,差异具有统计学意义(P<0.01);原发性高血压组与高血压心脏病组患者血浆中ox-LDL含量差异无统计学意义(P>0.05)。结论氧化型低密度脂蛋白的升高,从一定程度上提示ox-LDL可能与高血压病及高血压心脏病的机制有关,为进一步研究提供了依据。Objective To evaluate the level of oxidized low-density lipoprotein of hypertensive patients and to investigate the relationship between hypertensive disease and oxidized low-density lipoprotein.Methods 61 patients who hospitalized at the Central Hospital of Xuzhou were divided into two groups： hypertensive group（n=30） and hypertensive heart disease group（n=31）.30 healthy individuals were selected as the control group.The members were all volunteers.Measurement of oxidized low-density lipoprotein in plasma was performed by enzyme-linked immunosorbent assay.Results The level of oxidized low-density lipoprotein in the hypertensive group and hypertensive heart disease group were significantly higher than that of the control group（P0.01）.There was no difference between the hypertensive group and hypertensive heart disease group（P0.05）.Conclusion The elevation of ox-LDL was related to the mechanism of hypertension disease and hypertensive heart disease.It can offer basis for further research.

关 键 词：高血压病 高血压心脏病 氧化型低密度脂蛋白 

分 类 号：R544.1[医药卫生—心血管疾病] R541.3[医药卫生—内科学]