洛阳地区支气管哮喘患者吸入性变应原回顾分析  

Prevalence of Sensitization to Aeroallergensin Luoyang Patients with Bronchial Asthma

作　　者：雍磊[1] 程相铎[1] 董学文[1] 何静[1] 张彩霞[1] 贾丹[1] 

机构地区：[1]中国人民解放军第150中心医院变态反应中心,河南省洛阳市471031

出　　处：《中华全科医学》2013年第4期516-517,共2页Chinese Journal of General Practice

摘　　要：目的调查洛阳地区支气管哮喘患者的常见吸入性变应原。方法采用免疫印迹法变应原体外检测试剂盒,对1238例支气管哮喘患者血清中常见吸入变应原特异性IgE(SIgE)抗体测定,并将其中的356例4月～14岁的患者设为少儿组,与另外882例15岁及以上的成人组患者进行对比分析。结果 1238例支气管哮喘患者至少有一项过敏原特异性IgE阳性者占72.38%,二种或二种以上过敏原阳性者占57.12%,其中霉菌阳性率最高,其次为矮豚草、户尘螨。少儿组户尘螨、蟑螂阳性率明显大于成人组(P<0.01),而成人组矮豚草、霉菌及春季花粉阳性率明显大于少儿组(P<0.01)。结论霉菌是洛阳地区支气管哮喘患者的主要吸入性变应原,少儿与成人主要变应原不同。Objective To investigate the major aeroallergens in patients with bronchial asthma in Luoyang.Methods 1238 cases of bronchial asthma were divided into the children group（356）,and adult group（882）.The serum specific IgE antibodies to aeroallergens were tested by immunoblot assay in the sera from cases of bronchial asthma.Results Out of 1238 cases of bronchial asthma,72.38% of patients were positive with specific IgE antibodies,there were upwards two of allergens positive in 57.12% patients.The most aeroallergen was mould,and ragweed,dust of house in following.The positive rate of mould mixture and cockroach showed significantly higher（P0.01） in children than adult groups,however,the positive rate of ragweed pollen,mould mixture and spring pollen mixture showed significantly higher（P0.01） in adult than those in children group.Conclusion Mould had become a major aeroallergen for bronchial asthma in Luoyang in recent years and the kind of aeroallergen was different between children and adult.

关 键 词：支气管哮喘 免疫球蛋白E 吸入性变应原 免疫印迹 

分 类 号：R562.25[医药卫生—呼吸系统] R446.621[医药卫生—内科学]