加味泽泻方中挥发油环糊精包合物的制备及其对透皮扩散的影响研究  

Preparation of Cyclodextrin Inclusion Compound of Volatile Oil in Jiawei Zexie Fang and Study on its Effect of Transdermal Diffusion

作　　者：王琼[1] 王令充[1,2] 丁青龙 狄留庆[1,2] 陈国宝[4] 

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]江苏省中药高效给药系统工程技术研究中心,江苏南京210023 [3]常州102医院药剂科,江苏常州213000 [4]江阴市中医院药剂科,江苏江阴214400

出　　处：《南京中医药大学学报》2013年第2期182-186,共5页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省"青蓝工程"科技创新团队支持计划(2008)30号;江苏省优势学科支持计划(ysxk-2010)

摘　　要：目的制备加味泽泻方中挥发油的环糊精包合物,并对其透皮扩散的影响进行研究。方法分别采用饱和水溶液法和研磨法制备挥发油的环糊精包合物,用HPLC法测定其包合率及载药量,并对包合物的外观形态、稳定性、体外释放度及离体透皮实验进行研究。结果离体透皮实验证明,包合物24h药物累积释放量均低于挥发油/可溶性淀粉对照组,累积释放量排序为挥发油/HP-β-环糊精包合物>挥发油/DM-β-环糊精包合物>挥发油/β-环糊精包合物,与包合物的稳定性研究排序相反。结论加味泽泻方中挥发油/环糊精包合物延缓挥发油释放。OBJECTIVE To prepare cyclodextrin inclusion compound of volatile oil in Jiawei Zexie Fang and study its transdermal diffusion effect. METHODS Use saturated aqueous solution method and grinding method to prepare cyclodextrin inclusion compound of volatile oit respectively. The inclusion rate and drug loading were determined by HPLC. The appearance, stability, in vitro release and in vitro transdermal experiments were investigated. RESULTS The vitro transdermal delivery experiment showed that drug cumulative release of inclusion compound were lower than volatile oil/soluble starch control group in 24h and the order of drug release was as following, volatile oil/HP-β-cyclodextrin inclusion complex〉~volatile oil/DM-β-cyclo- dextrin inclusion complex^volatile oil/[3-cyclodextrin inclusion complex, which was contrary to the order of the inclusion com- pound stability study. CONCLUSION The volatile oil/cyclodextrin inclusion compound can delay the release of volatile oil extracted from Jiawei Zexie Fang.

关 键 词：加味泽泻方 挥发油 环糊精 包合物 透皮扩散 

分 类 号：R943[医药卫生—药剂学]