牛蒡子苷大鼠在体肠吸收动力学研究  

In vivo absorptive dynamics of arctiin in intestine of rats

作　　者：李沉纹[1] 罗明和[1] 李卓恒[1] 于彩平[1] 管海燕[1] 卢来春[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所药剂科,重庆400042

出　　处：《中草药》2013年第6期727-730,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目(30973908);重庆市攻关项目(2009AC5025);中小企业创新基金(HC26215113529)

摘　　要：目的研究牛蒡子苷在大鼠小肠内的吸收动力学特征。方法采用大鼠在体肠灌流方法建立牛蒡子苷大鼠肠吸收模型,考察牛蒡子苷在大鼠小肠的吸收情况,计算牛蒡子苷的吸收速率常数(Ka)、吸收半衰期(t1/2)、单位时间吸收率(P)、表观渗透系数(Papp)。结果牛蒡子苷10～50μg/mL在肠道吸收的Ka、t1/2、P、Papp值不随质量浓度的变化而变化,基本保持恒定。结论牛蒡子苷在大鼠体内的小肠吸收符合一级动力学过程,吸收机制为被动转运。Objective To investigate the in vivo absorptive characteristic of arctiin in small intestine of rats. Methods The intestine absorption model of arctiin was established by in vivo intestinal perfusion method. The absorption rate constants （Ka）, absorption half time （t1/2）, absorption percent of per unit of time （P）, and apparent permeability coefficient （/bapp） were calculated and compared to investigate the absorptive dynamics of arctiin in intestine of rats. Results At the concentration range of 10--50 μg/mL, Ka, t1/2, P, and Papp showed no significant difference, and had no connection with concentration of arctiin. Conclusion Arctiin complies with the first-order absorptive kinetics and the absorptive mechanism in intestine may be passive transport.

关 键 词：牛蒡子苷 肠吸收 动力学特性 在体肠灌流 被动转运 

分 类 号：R969.1[医药卫生—药理学]