硝苯地平对先兆早产孕妇及其胎儿的影响  

Impact of Nifedipine on pregnant women with threatened premature labor and their fetuses

作　　者：熊员红[1] 裴海英[1] 杨玲[1] 陈倩[1] 初晓丽[1] 

机构地区：[1]广州医学院附属深圳沙井人民医院产科,广东深圳518000

出　　处：《海南医学》2013年第7期980-982,共3页Hainan Medical Journal

基　　金：深圳市宝安区科技局项目(编号:20110493)

摘　　要：目的探讨先兆早产孕妇使用硝苯地平保胎的可靠性及安全性,并观察其使用对新生儿的影响。方法选取我院妇产科2011年6月至2012年6月间治疗的150例先兆孕妇及胎儿为研究对象。随机将其分为两组,实验组给予硝苯地平保胎治疗,对照组给予盐酸利托君治疗,观察硝苯地平及盐酸利托君治疗先兆早产的起效时间,维持时间,保胎成功率,血压、心率变化情况,比较治疗费用及药物副作用等情况。结果实验组平均宫缩被抑制时间明显短于对照组(P<0.05);抑制维持时间长于对照组(P<0.05);实验组有效率达93.33%,对照组为90.67%,两组差异无统计学意义(P>0.05);两组产妇血压均在正常范围内差异无统计学意义(P>0.05),但对照组患者心率明显高于实验组(P<0.05);实验组早产儿Apgar评分明显高于对照组(P<0.05),但在早产儿体重及入住NICU方面,两组差异无统计学意义(P>0.05);药物副作用方面实验组较对照组少,但差异无统计学意义(P>0.05);实验组产妇治疗费用低于对照组(P<0.05)。结论硝苯地平治疗先兆早产可以有效缩短起效时间,延长维持时间,且副作用较小,安全可靠,可在临床上推广使用。Objective To investigate the reliability and safety of Nifedipine for pregnant women with threatened premature labor, and observe their effects on newborns. Methods One hundred and fifty pregnant women with threatened premature labor and fetuses in our hospital from June 2011 to June 2012 were enrolled in this study. The patients were divided into two groups： the study group and the control group. Patients in the study group were treated with Nifedipine, while those in the control group were treated with ritodrine hydrochloride. The onset time, duration, fetus protection success rate, blood pressure, heart rate, costs and adverse reactions were observed. Results The time of the uterine contraction inhibited was significantly shorter in the study group than the control group （P〈0.05）. The inhibition maintain time was significantly longer in the study group than the control group （P〈0.05）. The effective rate was 93.33% in the study group and 90.67% in the control group, with statistically significant difference between the two groups （P〈0.05）. The blood pressure of the two groups was within the normal range, with no statistically significant difference （P〈0.05）. Heart rate in patients of the control group was significantly higher than the study group （P〈0.05）. The Apgar score of the preterm children in the study group was significantly higher than that in the control group （P〈0.05）. No statistically significant difference was found in the weight of preterm children and admission to Neonatal Intensive Care Unit （NICU）, P〈0.05. Drug side effects in the study group was slightly less than those in the control group, with no statistically significant difference （P〈0.05）. The costs of the study group was significantly lower than those in the control group （P〈0.05）. Conclusion For treating threatened premature labor, Nifedipine can effectively shorten the onset time, extend the maintenance time, and reduce side effects, which can be actively promoted in clinical prac

关 键 词：先兆早产 硝苯地平 盐酸利托君 早产儿 

分 类 号：R714.45[医药卫生—妇产科学]