390例抗菌药物致不良反应报告分析  

Adverse Drug Reactions Induced by Antibiotics: Analysis of 390 Cases

作　　者：李敏[1] 

机构地区：[1]南京医科大学附属常州妇幼保健院,江苏常州213003

出　　处：《中国医院用药评价与分析》2013年第2期169-172,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:了解抗菌药物致药品不良反应(ADR)的特点及规律,探讨ADR的预防措施,为临床合理用药提供参考。方法:回顾性分析2009—2011年常州妇幼保健院收集并上报的390例抗菌药物致ADR报告,对引起ADR的抗菌药物种类、给药途径、临床表现以及患者的年龄、性别、ADR史等方面进行统计、分析。结果:390例ADR报告共涉及9类30种抗菌药物,其中头孢菌素引起ADR最多(265例,占66.92%);给药途径方面,静脉滴注引起ADR最常见(362例,占92.82%);ADR累及器官和(或)系统及临床表现以皮肤及其附件损害居多(243例,占51.70%)。ADR的发生与患者年龄、给药途径、药物种类有关。结论:应规范抗菌药物的应用,严格操作,加强ADR监测和预警,以减少ADR的发生。OBJECTIVE：To investigate the characteristics and regularity of antibiotic-induced adverse drug reaction（ADR） and explore the prophylactic measures for ADR so as to provide reference for clinical rational use of antibiotics.METHODS： 390 antibiotic-induced ADR cases reported in Changzhou Maternal and Child Health Care Hospital during 2009-2011 were given statistical analysis retrospectively in terms of drug types,route of administration,clinical manifestation,gender age and ADR history of patients etc.RESULTS： 9 categories and 30 kinds of antibiotics drugs were involved in 390 ADR cases,among which cephalosporin dominated the first place with 265 cases（66.92%）;with regard to route of administration,362（92.82%） were induced by intravenous drip infusion.The main clinical manifestation of the ADR was lesion of skin and its appendants[243 cases（51.70%）].The ADR was associated with age of patients,route of administration and category of drugs.CONCLUSION： It is important to standardize the use of antibiotics by strictly abiding by operation rules and strengthen ADR monitoring and prewarning in an effort to reduce ADR occurrence.

关 键 词：抗菌药物 药品不良反应 分析 合理用药 

分 类 号：R969.3[医药卫生—药理学]