血管内皮细胞生长因子基因-2578C/A多态性与中国北方汉族人群银屑病易感性的相关性研究  

Association between the Single Nucleotide Polymorphisms in Vascular Endothelial Growth Factor Gene and Susceptibility of Psoriasis

作　　者：徐杰[1] 黄承志 黄承滨[3] 乔正学[4] 孙文靖[3] 

机构地区：[1]哈尔滨医科大学生理学教研室,黑龙江哈尔滨150081 [2]哈尔滨市中医医院手术室,黑龙江哈尔滨150010 [3]哈尔滨医科大学医学遗传学研究室,黑龙江哈尔滨150081 [4]哈尔滨医科大学医学心理学教研室,黑龙江哈尔滨150081

出　　处：《现代生物医学进展》2013年第4期678-680,共3页Progress in Modern Biomedicine

基　　金：黑龙江省教育厅面上项目(11521091)

摘　　要：目的:探讨血管内皮细胞生长因子(vascular endothelial cell growth factor,VEGF)基因-2578 C/A单核苷酸多态性位点与中国北方地区银屑病易感性的相关性。方法:随机收集2005年10月至2007年5月在哈尔滨医科大学附属一、二院皮肤科门诊就诊的246例寻常型银屑病患者(实验组)和271名正常对照个体(对照组)的外周静脉血,使用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法分析VEGF-2578 C/A多态位点基因型,并进行统计学分析。结果:在实验组中,VEGF-2578 C/A等位基因频率分别为74.80%、25.20%;在正常对照组中,VEGF-2578 C/A等位基因频率分别为76.59%、23.41%,两组VEGF-2578 C/A多态位点基因型的分布差异无统计学意义(P>0.05)。结论:VEGF基因-2578 C/A的多态性与中国北方汉族人群银屑病的易感性无明显相关性。Objective： To investigate the relationship between vascular endothelial growth factor（VEGF） polymorphisms and psoriasis in north of China.Methods： DNA genotyping was performed on peripheral blood leukocytes in 246 patients of psoriasis and 271 controls.One common polymorphism（2578） of VEGF gene was analyzed by PCR-RFLP.Results： In patients,the allele frequencies of the 2578 were as follows： C,74.80%;T,25.20%.In controls,the allele frequencies of 2578 were 76.59% and 23.41%,no significant difference of the genotype frequencies and allele frequencies in the polymorphic site was observed between the two groups.Conclusion： VEGF gene-2578 C/A polymorphism was probably not associated with the psoriasis susceptibility.

关 键 词：银屑病 血管内皮细胞生长因子 基因多态性 疾病易感性 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]