基质细胞衍生因子1α对急性ST段抬高型心肌梗死预后的预测价值  

Role of stromal cell-derived factor-1α in patients with acute ST-elevation myocardial infarction

作　　者：蔡星星[1] 李拥军[2] 马根山[2] 

机构地区：[1]南通大学附属医院心脏病科,江苏省226001 [2]东南大学附属中大医院心脏病科

出　　处：《江苏医药》2013年第7期791-793,共3页Jiangsu Medical Journal

摘　　要：目的探讨基质细胞衍生因子1α(SDF-1α)对急性ST段抬高型心肌梗死(STEMI)患者预后的预测价值。方法检测122例直接经皮冠状动脉介入治疗(PCI)的STEMI患者(A组)、70例慢性稳定性心绞痛(SAP)患者(B组)和70例冠状动脉造影正常者(C组)的血浆SDF-1α、肌钙蛋白I(cTnI)、空腹血糖、肌酐、血脂。A组随访10个月,根据有无发生主要心血管事件(MACE)分为事件组(A1组,35例)和无事件组(A2组,87例),筛选可独立预测MACE的指标。结果与B组、C组比较,A组SDF-1α水平降低(P<0.05);与A2组比较,A1组空腹血糖、肌酐及cTnI较高,SDF-1α偏低(P<0.05)。多元回归分析显示SDF-1α和cTnI可作为MACE的独立预测指标。结论血浆SDF-1α水平在STEMI患者中低表达,并可以独立预测其近期再发心血管事件的危险。Objective To investigate the value of stromal cell-derived factor-1α（SDF-la） in predicting the prognosis of patients with acute ST-elevation myocardial infarction（STEMI）. Methods Plasma SDF-1α, cardiac troponin I （cTnI）, fasting blood glucose （FBG）, serum creatintine （SCr） and lipids were determined in 122 patients（group A） with STEMI who underwent primary percutaneous coronary intervention（pCI）, 70 patients （group B） with stable angina pectoris （SAP） and 70 healthy adults（group C）, which were＇all confirmed by coronary angiography. The patients in group A were followed up for 10 months, during which major adverse cardiac events（MACE） were observed, on the basis of which they were divided into two groups of A1 （35 cases, with MACE） and A2 （87 cases, without MACE）. The parameters with significant difference between two groups were used for screening the risk factor to predict MACE. Results SDF-1α was significantly lower in group A than that in groups of B and C（〈0. 05）. Compared with group A2,FBG,SCr and cTnI of group A1 were higher, SDF-la was lower（P〈0. 05）. SDF-1α and cTnI were independent predictors for MACE when adjusted by FBG and SCr. Conclusion Lower plasma level of SDF-1α exists in the patients with STEMI,which may be taken as an independent predictor for the recurrent cardiovascular events in short-term.

关 键 词：基质细胞衍生因子1Α 急性心肌梗死 

分 类 号：R541[医药卫生—心血管疾病]