重度子痫前期患者母胎界面MRP1和MRP4 mRNA表达的研究  

Research of MRP1 and MRP4 expression in maternal-fetal interface of patients with severe preeclampsia.

作　　者：菅凤[1] 马玉燕[1] 刘振平[1] 张艳慧[1] 王琳琳[1] 

机构地区：[1]山东大学齐鲁医院妇产科,济南250012

出　　处：《现代妇产科进展》2013年第3期196-198,共3页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨多药耐药相关蛋白1(MRP1)和MRP4 mRNA在重度子痫前期患者母胎界面(胎盘和蜕膜)的表达及在其发病过程中的作用。方法:选取重度子痫前期患者21例及正常晚期妊娠29例(对照组)的胎盘和蜕膜组织,采用实时荧光定量RT-PCR法检测两组胎盘和蜕膜组织中MRP1和MRP4 mRNA的表达量。结果:重度子痫前期患者胎盘组织中MRP1和MRP4 mRNA的表达均较对照组显著升高(P均<0.05);与对照组相比,重度子痫前期患者蜕膜组织中MRP1和MRP4 mRNA的表达也明显升高(P均<0.05)。结论:MRP1和MRP4在重度子痫前期患者母胎界面的表达显著上调,可能参与了子痫前期的发病过程。Objective： To investigate the multidrug resistance-associated protein 1 （ MRP1 ） and MRP4 mRNA expression in severe preeelampsia maternal-fetal interface （ placenta and decidua） and the role in its pathogenesis. Methods：The placental and decidual tissues of 21 patients with severe preeclampsia and 29 cases of normal late pregnancy （the control group） were collected. The real-time fluorescent quantitative RT-PCR method was used to detect the mRNA expressions of MRP1 and MRP4 in the two group placental and decidual tissues. Results：Placenta MRP1 and MRP4 expressions in severe preeclampsia group were significantly higher than that in the control group （P〈0.05,P〈0.05）. Also, compared to the control group, decidua MRP1 and MRP4 expressions in severe preeclampsia group were obviously increased（P〈0.05 ,P〈0.05）. Conclusion：The expressions of MRP1 and MRP4 are remarkably up-regulated in maternal-fetal interface of severe preeclampsia, and may be involved in the pathogenesis of preeclampsia.

关 键 词：多药耐药相关蛋白质类 MRP1 MRP4 子痫前期 胎盘 蜕膜 母胎界面 

分 类 号：R714.24[医药卫生—妇产科学]