参归片对脑缺血损伤的保护作用  

Protective effect of anti-hypoxia shenggui tablet on cerebral ischemia injure

作　　者：石永平[1] 汪汇[2] 王怀新[1] 王金达[1,3] 王汝欢[1,3] 张雁芳[3] 崔文玉[3] 段炼[2] 汪海[3] 

机构地区：[1]北京赛德维康医药研究院,北京100039 [2]军事医学科学院附属医院,北京100071 [3]军事医学科学院卫生学环境医学研究所,北京100850

出　　处：《中国应用生理学杂志》2013年第2期139-141,146,共4页Chinese Journal of Applied Physiology

摘　　要：目的:探讨参归片对小鼠断头急性脑缺血和大鼠双侧颈总动脉结扎脑缺血的保护作用。方法:在断头小鼠急性脑缺血模型中,观察参归片(0.16、0.33、1.00 g/kg)连续灌胃30 d,对断头小鼠喘息时间的影响;在结扎双侧颈总动脉大鼠脑缺血模型中,观察参归片(0.072、0.149、0.450 g/kg)连续灌胃7 d,对急性脑缺血大鼠脑指数、脑组织中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量的影响。结果:与正常对照组相比,参归片中、高剂量组能显著延长断头小鼠喘气时间;与模型组相比,参归片低、中、高剂量组可显著降低脑指数的升高(P<0.05或P<0.01)、提高脑组织中SOD活性(P<0.01),高剂量组可显著降低脑组织中MDA含量(P<0.01)。结论:参归片对脑缺血损伤具有保护作用。Objective： To investigate the protective effects of Shengui tablet （Chinese Traditional Medicine） on experimental cerebral is chemia by acute cerebral ischemia hypoxia in mice and bilateral ligation of the carotid artery in rats. Melthods： In the acute cerebral ischemia hypoxia model, the mice were randomly divided into control group, low middleand high-dose （0.16, 0.33 and 1.00 g/kg） groups of Shengui tablet, after oral treatment for 30 d, gasping time of isolated heads of mice were observed. In bilateral ligation of the carotid artery cerebral ischemia model, the rats were randomly divided into control group, model group and low-, middle-, high-dose （0.072, 0. 149 and 0.450 g/kg） groups of Shengui tablet. After oral treatment for 7 d, the cerebral index, superoxide dismutase （SOD） activity and the content of malondialdehyde （MDA） were measured. Results： Compared with the control model, Shengui tablet middle- and high-dose could significantly prolong gasping time of isolate heads of mice. Compared with model group, Shengui tablet low-, middle- and high-dose could significandy decrease the cerebral index and enhance SOD activity in brain tissue; only high-dose could reduce the content of MDA. Conclusion： Shengui tablet has significant protective effect on the cerebral ischemia.

关 键 词：参归片 尼莫地平 脑缺血 SOD MDA 

分 类 号：R285.5[医药卫生—中药学]