β3肾上腺素受体基因Trp64Arg多态性与中国男性2型糖尿病患者合并高尿酸血症的相关性研究(英文)  

Effect of β3-adrenergic receptor gene Trp64Arg polymorphism on uric acid levels in a Chinese male type 2diabetes mellitus population

作　　者：黄琼[1] 张留福[2] 程雁[3] 司力[4] 魏伟[1] 

机构地区：[1]安徽医科大学临床药理研究所抗炎免疫药物教育部重点实验室 [2]安徽医科大学第三附属医院合肥市第一人民医院神经内科 [3]安徽医科大学第一附属医院儿科 [4]安徽医科大学第一附属医院检验科

出　　处：《中国临床药理学与治疗学》2013年第3期307-312,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：supported by the National Natural Science Foundation of China Grants(81202596);Specialized Research Fund for the Doctoral Program of Higher Education(20113420120006);Grants for Scientific Research of BSKY(XJ201021) from Anhui Medical University,Research Foundation of Anhui Medical University(2011xkj011);Anhui province Nature Science Foundation in University(KJ2012Z158)

摘　　要：目的:探讨中国人群男性2型糖尿病患者中β3肾上腺素受体基因Trp64Arg多态性与高尿酸血症的相关性。方法:196名高尿酸血症的2型糖尿病患者和196名正常尿酸水平的2型糖尿病患者进行基因分型。检测体重指数、腰臀比、收缩压、舒张压、血尿酸、肌酐、尿素氮、甘油三酯、低密度脂蛋白胆固醇脂、高密度脂蛋白胆固醇脂、空腹血糖和餐后血糖的水平。结果:高尿酸血症组中,携带不同β3肾上腺素受体Trp64Arg基因型的2型糖尿病患者其尿酸水平有统计学差异,且呈基因剂量效应[CC组(599.53±113.70)vsCT组(529.78±81.10)vs TT组(507.33±74.27),P<0.01]。在该研究中,Trp64Arg TC+CC基因型患者的血尿酸水平亦显著高于TT基因型组[(557.95±99.91)vs(503.47±69.40)μmol/L,P<0.01]。结论:β3肾上腺素受体基因Trp64Arg多态性与2型糖尿病合并高尿酸血症的具有相关性。AIM. To investigate the associa- tion of 133-adrenergic receptor gene Trp64Arg polymorphism with hyperuricemia in a Chinese male type 2 diabetes mellitus patients popula- tion. METHODS：196 hyperuricemic and 196 nor- mouricemic male subjects were genotyped in this study. Body mass index （BMI）, waist to hip ra- tio （WHR）, systolic blood pressure （SBP）, di- astolic blood pressure （DBP）, serum uric acid, urea nitrogen, creatinine, triglyceride, total cholesterol, low-density lipoprotein-cholesterol （LDL-C）, high-density lipoprotein-cholesterol （HDL-C）, fasting plasma glucose （FPG）, post- prandial plasma glucose （PPG） were detected. RESULTS： We found patients with different Trp64Arg genotype showed significant differ- ences in average uric acid concentrations （599.53±113.70 vs 529.78±81.10 vs 507.33±74.27, P〈0.01） among CC, CT and TT genotype and there were signiicantly higher average uric acid concentranons m individuals （ 557. xmol/L, subjects P^0. in the h Trp64Arg TC q- CC genotype 95 ± 99.91 vs 503.47 ± 69.40 01） than those TT genotype yperuricemic group. CONCLU- SION： Trp64Arg polymorphism was associated with hyperuricemia in a Chinese male population with type 2 diabetes mellitus.

关 键 词：Β3肾上腺素受体 基因多态性 高尿酸血症 尿酸 2型糖尿病 相关性分析 

分 类 号：R587.1[医药卫生—内分泌]