细胞-支架复合物构建组织工程肌腱研究进展  

RESEARCH PROGRESS OF CELL-SCAFFOLD COMPLEX IN TENDON TISSUE ENGINEERING

作　　者：朱颖[1] 李敏[1] 

机构地区：[1]福建师范大学生命科学学院,福州350108

出　　处：《中国修复重建外科杂志》2013年第4期481-485,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：福建省科技厅重点项目(2010Y0020)~~

摘　　要：目的对细胞-支架复合物构建组织工程肌腱的研究进展进行综述。方法查阅近年来肌腱组织工程中细胞-支架复合物的相关文献,并进行综述,从支架材料、种子细胞、培养方法和应用方面阐述细胞-支架复合物的研究概况。结果肌腱组织工程主要通过对支架材料进行修饰,并复合合适的种子细胞构建细胞-支架复合物。对于复合材料中细胞的培养有多种方法,尤其是力学刺激的应用,能有效促进细胞功能发挥。多种肌腱缺损动物模型研究表明,采用细胞-支架复合物有良好的修复效果。结论细胞-支架复合物构建组织工程肌腱是目前的研究热点,虽还未达到临床使用要求,但已显示了广阔的应用前景。Objective To review the research progress of cell-scaffold complex in the tendon tissue engineering. Methods Recent literature concerning cell-scaffold complex in the tendon tissue engineering was reviewed, the research situation of the cell-scaffold complex was elaborated in the aspects of seed cells, scaffolds, cell culture, and application. Results In tendon tissue engineering, a cell-scaffold complex is built by appropriate seed cells and engineered scaffolds. Experiments showed that modified seed cells had better therapeutic effects. Further, scaffold functionality could be improved through surface modification, growth factor cure, mechanical stimulation, and contact guidance. Among these methods, mechanical stimulation revealed the most significant results in promoting cell proliferation and function. Through a variety of defect models, it is demonstrated that the use of cell-scaffold complex could achieve satisfactory results for tendon regeneration. Conclusion The cell-scaffold complex for tendon tissue engineering is a popular research topic. Although it has not yet met the requirement of clinical use, it has broad application prospects.

关 键 词：肌腱组织工程 种子细胞 支架材料 力学刺激 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]