甲强龙与地塞米松治疗突发性聋的对比研究  

Comparative study of methylprednisolone and dexamethasone in treatment of sudden deafness

作　　者：汪建[1] 武肖娜[2] 彭华[1] 

机构地区：[1]广州军区广州总医院耳鼻咽喉科,广东广州510010 [2]广州军区广州总医院神经内科,广东广州510010

出　　处：《中国耳鼻咽喉头颈外科》2013年第3期123-125,共3页Chinese Archives of Otolaryngology-Head and Neck Surgery

摘　　要：目的回顾性对比分析不同剂量甲强龙(methylprednisolone,MP)和地塞米松(dexamethasone,DX)治疗突发性聋临床疗效。方法对88例单侧起病突发性聋患者进行回顾性分析,分为MP组(42例)及DX组(46例),在起病72 h内分别将MP 80 mg或DX 15 mg加入0.9%氯化钠溶液100 ml中静脉滴注,1次/d,连续使用5 d,(10±2)d比较两组患者的临床有效率及对糖尿病患者血糖的影响。结果治疗(10±2)d,临床总有效率MP组(85.71%)和DX组(84.8%)之间无明显差异(P>0.05),MP组血糖升高人数百分比(28.6%)明显小于DX组(61.1%,χ2=5.707,P<0.05)。结论 MP和DX治疗急性期突发性聋中均可及时有效地缓解临床症状,糖尿病患者突发性聋的治疗MP相对于DX对血糖的影响较小。OBJECTIVE A retrospective comparative analysis was conducted on the clinical efficacy of methylprednisolone （MP） and dexamethasone （DX） in treatment of sudden deafness （SD） . METHODS The data of 88 patients with SD of unilateral outset were retrospectively analyzed. They were divided into two groups： MP group （42 cases） and DX group （46 cases） , and were given intravenous infusion with MP 80mg or DX 15 mg respectively in 0.9% sodium chloride solution 100 ml in 72 hours after onset, once a day, for 5 days. After （10±2） days, the clinical efficiency of two groups was analysed. RESULTS After treatment for （10±2） days, the clinical total effective rate of MP group （85.71%） had no significant difference compared with that of DX group （84.8%, P〉0.05） . The percentage of blood glucose elevated patients （28.6%） in MP group was significantly lower than that in DX group （61.1%,X^2=5.707, P〈0.05） . CONCLUSION In the treatment of SD, both MP and DX can relief the clinical symptoms effectively; MP has smaller effect on blood glucos compared with DX in treatment of SD patients with diabetes.

关 键 词：听觉丧失 突发性 临床方案 糖皮质激素类 糖尿病 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]