噻托溴铵对不同表型慢性阻塞性肺疾病患者的疗效观察  

The Therapeutic effect of Tiotropium on Patients with Chronic Obstructive Pulmonary Disease of Different Phenotypes

作　　者：李继琼[1] 

机构地区：[1]成都市第二人民医院呼吸内科,成都610017

出　　处：《华西医学》2013年第2期172-174,共3页West China Medical Journal

摘　　要：目的评价噻托溴铵对不同表型慢性阻塞性肺疾病(COPD)患者的疗效。方法选取2008年10月-2010年5月COPD患者81例,根据胸部高分辨率CT上的形态表现分型,以气道病变为主型纳入A组,以肺气肿为主型纳入B组,按方案吸入噻托溴铵,在给药前后分别测定肺功能、圣乔治呼吸问卷评分(SGRQ)及6 min步行距离。结果用药3个月后A组的第1秒用力肺活量(FEV1)、用力肺活量(FVC)、FEV1/FVC及FEV1占预计值(%)比B组明显提高,两组比较差异有统计学意义(P<0.05),SGRQ评分比较B组明显下降,运动耐力(6 min步行距离)增加(P<0.05)。结论噻托溴铵在COPD的治疗中,针对不同的表型,其疗效不同。Objective To evaluate the effect of tiotropium on patients with chronic obstructive pulmonary disease（COPD） of different phenotypes.Methods Between October 2008 and May 2010,81 patients with COPD were divided into two groups according to phenotypes shown on high-definition CT.Group A patients had a major abnormality in the trachea,while patients in group B had emphysema.Both groups received the same therapy of tiotropium.Before and after the patients took medicine,lung function,6 min walking distance and St.George＇s Respiratory Questionnaire score were detected.Results Three months later,FEV1,FVC,FEV1/FVC,and FEVl/prediction value of group A were significantly higher than those of group B（P0.05）.Six min walking distance and all scores of St.George＇s Respiratory Questionnaire were improved significantly（P0.05）.Conclusion The present study confirms that the effect of tiotropium is distinct to patients with COPD of different phenotypes.

关 键 词：慢性阻塞性肺疾病 肺功能 运动耐量 噻托溴铵 

分 类 号：R563.9[医药卫生—呼吸系统]