可即邦胶原蛋白海绵在控制膝关节置换术后出血中的价值  

The significance of Kejibang collagen sponge in controlling bleeding after knee arthroplasty

作　　者：彭锦辉[1] 钱齐荣[1] 刘宁 徐炜[1] 周嵘[1] 王智巍[1] 张灏[1] 

机构地区：[1]第二军医大学附属长征医院骨科,上海200003 [2]解放军88医院,泰安271001

出　　处：《中国骨与关节杂志》2013年第3期155-158,共4页Chinese Journal of Bone and Joint

摘　　要：目的探讨可即邦医用胶原蛋白海绵(collagen sponge,CS)在控制全膝关节置换术后出血中的应用价值。方法选取2011年6月至2012年6月,142例患者,男37例,女105例,平均年龄68.7岁。随机分为两组,常规进行膝关节置换,CS组71例,术中使用可即邦医用胶原蛋白海绵,另71例术中未予使用,作为对照组。对每个患者我们均记录术后可见失血量、术中失血量、总失血量、术前术后血红蛋白值、两组中的输血患者数,以及并发症等。结果 CS组术后可见失血量为(195.3±37.0)ml,对照组(279.2±40.1)ml,两组差异有统计学意义(P=0.047)。CS组和对照组患者术后24h血红蛋白下降值分别为(30.3±3.4)g/L、(39.2±4.7)g/L,差异有统计学意义(P<0.01)。CS组和对照组分别有10例和21例患者输血,术后输血人数差异有统计学意义(P=0.025)。两组中各有1例患者发生深静脉血栓;CS组术后发生1例切口表浅部位感染,1例切口表浅皮肤坏死,对照组有1例切口表浅部位感染。差异均无统计学意义。结论可即邦医用胶原蛋白海绵可以有效降低TKA的术后失血量。Objective To investigate the effects of Kejibang medical collagen sponge （CS） in controlling post-operative bleeding following total knee replacement surgery. Methods From June 2011 to June 2012, 142 patients （37 males and 105 females, mean age 68.7 years） were randomly divided into 2 groups prior to conventional knee replacements. CS group： 71 cases using medical collagen sponge during the surgery. Control group： 71 cases without the use of CS during the surgery. Each patient was monitored and recorded for visible blood loss, intra-operative blood loss, total blood loss, pre-operative and post-operative hemoglobin values, the amounts of patients accepting blood transfusion in 2 groups, as well as any complications. Results The CS group visible blood loss after the surgery was （195.3±37.0） ml. Compared with （279.2±40.1） ml of the control group, the differences were statistically significant （P=0.047）. 24-hour hemoglobin drop level in CS group and control group patients were （30.3±3.4） g/L and （39.2±4.7） g/L, respectively. The differences were statistically significant （P〈0.01）. CS group and the control group contained 10 cases and 21 cases respectively requiring post-operative blood transfusion. The differences were statistically significant （P=0.025）. During postoperative care, there was 1 patient with deep venous thrombosis in each group. In CS group there was 1 case of superficial incision site infection, and 1 case of superficial incision site skin necrosis. The control group contained 1 case of superficial incision site infection. The differences were not statistically significant. Conclusions The use of Kejibangmedical collagen sponge can effectively reduce total knee arthroplasty post-operative blood loss.

关 键 词：胶原蛋白海绵 关节成形术 置换 膝 失血 

分 类 号：R687.4[医药卫生—骨科学] R961[医药卫生—外科学]