软骨标志物CTX-Ⅱ在骨关节炎中的应用  

Application of biomarker CTX-Ⅱ in osteoarthritis

作　　者：王学宗[1] 高宁阳[1] 刘婷[1] 沈军[1] 韦宋谱[1] 郑昱新[1] 曹月龙[1,2] 詹红生[1,2] 

机构地区：[1]上海中医药大学附属曙光医院,上海201203 [2]上海市中医药研究院骨伤科研究所,上海201203

出　　处：《中国骨伤》2013年第3期260-263,共4页China Journal of Orthopaedics and Traumatology

基　　金："中医骨伤科学"国家重点学科(编号:100508);国家自然科学基金(编号:81072830;81173277);上海市教委创新项目(编号:11YZ64)~~

摘　　要：骨关节炎(OA)的临床诊断尚缺乏有效的生物学标志物。研究证实标志物Ⅱ型胶原羧基端交联肽(CTX-Ⅱ)是关节软骨降解的特异性指标。CTX-Ⅱ检测可及时反映软骨损伤和退变程度、诊断OA发生、预测OA进展和监测药物治疗效果,从而间接反映OA患者的病情。CTX-Ⅱ的应用主要集中于OA早期,并需联合其他生物学标志物一起检测,以便更准确的反映OA病变,但其检测结果具体临床指导意义还需进一步完善。Effective biomarkers for clinical usage of osteoarthritis are still limited. It was confirmed that C-terminal crosslinking telopeptide of type Ⅱ collagen （CTX-Ⅱ ） was a specific marker reflecting degradation of articular cartilage. Detec- tion of CTX- Ⅱcould promptly ref/ect level of cartilage injury and degradation, diagnose OA, predict its progress, monitor effects of drug treatment, thus, reflect the condition of osteoarthritis patient indirectly. Application of CTX-Ⅱ focused mainly on in the early stage of OA and need together to detect with other biomarkers,in order to more accurately reflection of the patho- logical changes of OA,but the specific clinical significance of CTX-Ⅱ results still need to improve further.

关 键 词：骨关节炎 软骨 综述文献 

分 类 号：R992[医药卫生—毒理学]