蛋白质组学在股骨头坏死中的研究进展  

Research progress on proteomics in femur head necrosis

作　　者：胡淼锋[1] 周晓成[1] 单乐天[1] 肖鲁伟[1] 童培建[2] 

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江省中医院骨科,浙江杭州310006

出　　处：《中国骨伤》2013年第3期264-266,共3页China Journal of Orthopaedics and Traumatology

基　　金：国家自然科学基金(编号:81072820)~~

摘　　要：蛋白质组学技术的兴起能快速筛选并鉴定疾病的特异性生物标记物,有助于揭示股骨头坏死的发生机制,早期诊断,从而寻找更有效的治疗方法和治疗靶点。目前以找出其发生机制、早期诊断和早期治疗的相关蛋白及其功能鉴定,建立相关数据库及蛋白提取方法的优化为研究热点和焦点。本文综述近年来股骨头坏死相关的蛋白质研究技术及其在股骨头坏死患者骨组织、血清及相关动物模型中运用,为进一步研究提供思路。Appearance of proteomics technology can fleetly lilt and reveal specificity biomarkers of disease, this will help to reveal the pathogenesis of femur head necrosis and help early diagnosis ,find more effective methods and therapeutic targets. At present, they are hot spots that find out the occurred mechanism, related proteins of early diagnosis and early treatment and its functional identification;set up the early related database; optimize the protein extraction methods for research of femur head necrosis. This article reviews the application of study technology of related proteins of femur head necrosis on bone tissue, serum, related animal model, and in order to provide further research ideas.

关 键 词：股骨头坏死 蛋白质组学 综述文献 

分 类 号：R392.11[医药卫生—免疫学]