慢性肾脏病患者晨尿微量白蛋白/尿肌酐比值与24h尿蛋白定量的相关性分析  

The correlation analysis of morning urine microalbumin/urine creatinine and 24 h urine protein quantification in patients with chronic kidney disease

作　　者：邱杰山[1] 沈水娟[1] 刘琪[1] 李青华[1] 胡作祥[1] 

机构地区：[1]浙江省绍兴市人民医院,浙江绍兴312000

出　　处：《中国卫生检验杂志》2013年第3期693-696,共4页Chinese Journal of Health Laboratory Technology

基　　金：浙江省医学会临床科研基金(2011ZYC-A86)

摘　　要：目的:分析慢性肾脏病(CKD)患者晨尿微量白蛋白/尿肌酐比值(晨尿ACR)与24 h尿蛋白定量的相关性,探讨晨尿ACR取代24 h尿蛋白定量测定的价值。方法:收集CKD1-5期患者265例,分别对CKD1期、CKD2期、CKD3期、CKD4期、CKD5期及所有CKD1-5期患者晨尿ACR与24 h尿蛋白定量做相关分析。分别以0.15 g≤24 h尿蛋白<1 g、1 g≤24 h尿蛋白<3.5 g和24 h尿蛋白≥3.5 g作为界点,通过ROC曲线确定其相应的晨尿ACR诊断界值。结果:CKD1期、CKD2期、CKD3期、CKD4期、CKD5期及所有CKD1-5期患者晨尿ACR与24 h尿蛋白定量呈正相关。以0.15 g≤24 h尿蛋白<1 g、1 g≤24 h尿蛋白<3.5 g和24 h尿蛋白≥3.5 g分别作为界点,其对应的晨尿ACR诊断界值分别为0.210 g/gcr、1.508 g/gcr和4.137 g/gcr。结论:CKD患者晨尿ACR可作为替代24 h尿蛋白定量测定的指标。Objective：To analyze the correlation between morning urine albumin/urine creatinine（morning urine ACR） and 24 h urine protein quantity in patients with chronic kidney disease, so as to investigate the value of morn- ing urine ACR in replacement of 24 h urine protein quantity. Methods ： Morning urine ACR and 24 h urine protein quantity were collected from 265 patients with CKD. And the linear correlation analysis between morning urine ACR and 24 h urine protein quantity was done for the patients of CKD1, CKD2, CKD3, CKIM, CKD5 and CKDI - 5 respectively. Setting the point of 0. 15 g ≤ 24 h urine protein quantity 〈 1 g, 1 g ≤24 h urine protein quantity 〈 3.5 g and urine protein quantity ≥3.5 g as the critical point respectively, to determine the corresponding value of morning urine ACR diagnostic sector by ROC curve. Results： Morning urine ACR and 24 h urinary protein quantity were positively correlated respectively in patients of CKD1, CKD2, CKD3, CKD4, CKD5 and CKD1 -5. As the criti- cal points were 0.15 g≤24 h urine protein quantity 〈 1 g,1 g ≤24 h urine protein quantity 〈3.5 g and urine pro- tein quantity ≥ 3. 5 g, the corresponding value of morning urine ACR diagnostic sector were 0. 210 g/gcr, 1. 508 g/gcr, 4. 137 g/gcr respectively. Conclusion： Morning urine ACR can be used as an alternative biomarker for 24 h urine protein quantity in patients with CKD.

关 键 词：慢性肾脏病 晨尿微量白蛋白 尿肌酐 24 h尿蛋白定量 

分 类 号：R692[医药卫生—泌尿科学]