慢性肾衰患者血清高分子量脂联素多聚体水平的临床意义  

The clinical significance of serum high-molecular-weight adiponectin multimer level in CRF patients

作　　者：俞燕[1] 王卫忠[1] 

机构地区：[1]浙江省人民医院,杭州310014

出　　处：《中国卫生检验杂志》2013年第3期697-698,701,共3页Chinese Journal of Health Laboratory Technology

基　　金：浙江省医学重点学科基金(07-010)

摘　　要：目的:探讨慢性肾功能衰竭(CRF)患者血清高分子量脂联素多聚体(HMW-APN)水平及临床意义。方法:ELISA方法测定55例非血液透析的CRF患者(A组),58例血液透析的CRF患者(B组)和50例健康人(C组)血清HMW-APN、总APN水平、肾功能和血脂,并测定颈动脉内膜-中膜厚度(IMT)及粥样斑块发生率,分析各指标间的相关性。结果:1.A和B组血清HMW-APN、总APN水平等均高于C组,B组IMT厚度和粥样斑块发生率均高于A组(P<0.05),B组血清HMW-APN水平低于A组(P<0.05);2.HMW-APN水平与甘油三酯(TG)呈负相关(r=-0.312,P<0.05),与尿素氮(BUN)、肌酐(Cr)呈正相关(r=0.713、0.512,P<0.05);总APN水平与肌酐(Cr)呈正相关(r=0.681,P<0.05)。结论:同时检测HMW-APN和总APN的水平是观察CRF的一个较好的指标。Objective： To investigate the level and clinical significance of serum High - Molecular - Weight complex of adiponectin（ HMW- APN） in chronic renal failure（CRF） patients. Methods： The levels of HMW -APN and total APN, renal function and blood lipid in 55 non - hemodialysis CRF patients （ Group A）, 58 hemodialysis CRF patients（ Group B） and 50 healthy people （Group C ） were measured by ELISA, and the carotid intima - media thickness （IMT） and plaque prevalence were determined, then the correlation among different indicators were analyzed. Results： 1. Serum HMW - APN, total APN levels of Group A and Group B were significantly higher than those of Group C （P 〈 0.05 ）, serum HMW - APN levels of Group B were significantly lower than those of Group A, while IMT and prevalence of carotid artery plaque of Group B were higher than those of Group A （P 〈 0.05 ）. 2. Se- rum HMW- APN levels were negatively correlated to TG（r = -0. 312,P 〈0.05） and positively relatived to BUN, Cr（r =0. 713,0. 512 ,P 〈 0.05 ） ; Serum total APN levels were positively relatived to Cr（ r = 0. 681 ,P 〈 0.05 ）. Conclusion： Simultaneous detection of HMW - APN and total APN will be a very good indicator to observe CRF.

关 键 词：脂联素 多聚体 酶联免疫吸附法 慢性肾衰 

分 类 号：R692.5[医药卫生—泌尿科学]