Synthesis and cytotoxicity of dinuclear platinum(Ⅱ) complexes of(1S,3S)-1,2,3,4-tetrahydroisoquinolines  

作　　者：Geng Xu Ju Guo Zheng Yan Nan Wang Zhan-Zhu Liu 

机构地区：[1]State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica,Peking Union Medical College and Chinese Academy of Medical Sciences [2]Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation,Institute of Materia Medica,Peking Union Medical College and Chinese Academy of Medical Sciences

出　　处：《Chinese Chemical Letters》2013年第3期186-188,共3页中国化学快报（英文版）

摘　　要：A series of novel dinuclear platinum（II） complexes with （IS, 3S）-l,2,3,4-tetrahydroisoquinolines as the ligands were synthesized as potential anticancer agents in several steps starting from commercially available L-DOPA. The cytotoxicities of the series of dinuclear platinum（n） complexes of tetrahydroisoquinoline were tested against HCT-8, BEL-7402, A2780, MCF-7, Hela, A549 and BGC-823 cell lines by the MTT test. These complexes showed selective inhibition activity against cisplatin-insensitive cell line Skov3.A series of novel dinuclear platinum（II） complexes with （IS, 3S）-l,2,3,4-tetrahydroisoquinolines as the ligands were synthesized as potential anticancer agents in several steps starting from commercially available L-DOPA. The cytotoxicities of the series of dinuclear platinum（n） complexes of tetrahydroisoquinoline were tested against HCT-8, BEL-7402, A2780, MCF-7, Hela, A549 and BGC-823 cell lines by the MTT test. These complexes showed selective inhibition activity against cisplatin-insensitive cell line Skov3.

关 键 词：Dinuclear platinum（ll） complexesAntitumor activityTetrahydroisoquinolinesSynthesis 

分 类 号：TQ463.6[化学工程—制药化工]