An efficient synthesis of novel chromeno[3',4':5,6]pyrano[2,3-b]indole derivatives  

作　　者：Zhi-Wei Chen Na Zhang Zhi-Hua Wang Wei-Ke Su 

机构地区：[1]Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education,College of Pharmaceutical Sciences,Zhejiang University of Technology

出　　处：《Chinese Chemical Letters》2013年第3期199-201,共3页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.21176222);Zhejiang Key Innovation Team of Green Pharmaceutical Technology for financial support

摘　　要：An efficient two-step method was described for the synthesis of chromeno[3＇,4＇：5,6]pyrano[2,3-blindole derivatives. The three-component reaction of 4-hydroxycoumarin, variously substituted benzaldehydes and indolin-2-one was promoted by P205 in refiuxing ethanol to give trimolecular adducts, which were then cyclized in 1,2-dichloroethane under reflux using POCI3.An efficient two-step method was described for the synthesis of chromeno[3＇,4＇：5,6]pyrano[2,3-blindole derivatives. The three-component reaction of 4-hydroxycoumarin, variously substituted benzaldehydes and indolin-2-one was promoted by P205 in refiuxing ethanol to give trimolecular adducts, which were then cyclized in 1,2-dichloroethane under reflux using POCI3.

关 键 词：Pyranochromenelndolin-2-one4-HydroxycoumarinMulticomponent reactionIntramolecular cyclization 

分 类 号：O626[理学—有机化学]