Design and synthesis of new 7,8-dimethoxy-α-naphthoflavones as CYP1A1 inhibitors  

作　　者：Jia-Hua Cui Dagula Hu Xu Zhang Zheng Jing Jing Ding Ru-Bing Wang Shao-Shun Li 

机构地区：[1]School of Pharmacy,Shanghai Jiaotong University

出　　处：《Chinese Chemical Letters》2013年第3期215-218,共4页中国化学快报（英文版）

基　　金：supported by the State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources,Ministry of Science and Technology of China (No.CHEMR2012-B08)

摘　　要：The flavonoids as inhibitors of CYP1A1 exhibit chemopreventive effects against certain procarcinogens and have been considered as the promising cancer preventive agents. A series of novel 7,8-dimethoxy-a- naphthoflavones as the substrate analogs were designed and prepared, The enzyme assay suggested that all of these new flavones were stronger inhibitors of CYP1A1 than the lead compound a-naphthoflavone, Among the tested ones, 3h showed the most potent inhibitory effects,The flavonoids as inhibitors of CYP1A1 exhibit chemopreventive effects against certain procarcinogens and have been considered as the promising cancer preventive agents. A series of novel 7,8-dimethoxy-a- naphthoflavones as the substrate analogs were designed and prepared, The enzyme assay suggested that all of these new flavones were stronger inhibitors of CYP1A1 than the lead compound a-naphthoflavone, Among the tested ones, 3h showed the most potent inhibitory effects,

关 键 词：a-NaphthoflavoneCYPIA1 inhibitors7 8-Dimethoxy-a-naphthoflavoneFlavonoids 

分 类 号：TQ463[化学工程—制药化工]