A facile synthesis of the oxazolidinone antibacterial agent linezolid  

作　　者：Yan-Wu Li Yan Liu Yun-Can Jia Jian-Yong Yuan 

机构地区：[1]Institute of Life Science & Pharmacy College,Chongqing Medical University

出　　处：《Chinese Chemical Letters》2013年第3期230-232,共3页中国化学快报（英文版）

基　　金：supported by Natural Science Foundation Project of CQ CSTC

摘　　要：A facile synthetic route of linezolid 1 has been developed. Using commercially available （R）- epichlorohydrin as the starting material, 1 was obtained through a sequence of cyclization, substitution, a Goldberg coupling, aminolysis and acetylation reactions. The synthetic route is easy to perform and can be scaled up.A facile synthetic route of linezolid 1 has been developed. Using commercially available （R）- epichlorohydrin as the starting material, 1 was obtained through a sequence of cyclization, substitution, a Goldberg coupling, aminolysis and acetylation reactions. The synthetic route is easy to perform and can be scaled up.

关 键 词：LinezolidSynthesisGoldberg coupling reaction 

分 类 号：TQ465[化学工程—制药化工]