二肽基肽酶Ⅳ抑制剂的药理作用及其机制研究  

Research progress in pharmacologic actions of dipeptidyl peptidase IV inhibitors and its mechanism

作　　者：孟艳秋[1] 张宇[1] 刘凤鑫[1] 刘文虎[1] 庞舒月[1] 

机构地区：[1]沈阳化工大学制药工程教研室,辽宁沈阳110142

出　　处：《现代药物与临床》2013年第2期101-107,共7页Drugs & Clinic

基　　金：辽宁省重点大学科学研究项目(L2010433)

摘　　要：近些年来,二肽基肽酶Ⅳ(dipeptidyl peptidase IV,DPP-IV)抑制剂在治疗2型糖尿病的药物中异军突起,DPP-IV是一种2型多功能跨膜细胞表面糖基化蛋白,在临床治疗和临床试验中,发现了很多DPP-IV抑制剂潜在的药理作用。通过对国内外相关文献的检索,对DPP-IV抑制剂包括降糖、保护心脏、抗炎等药理作用进行了综述。In recent years,the dipeptidyl peptidase IV（DPP-IV） inhibitors have been used for the treatment of type 2 diabetes.DPP-IV inhibitor is a kind of type 2 multifunctional transmembrane cell surface glycosylation protein,and lots of the potential pharmacological effects of DPP-IV inhibitors have been reported in the clinical treatment and trials.In this paper,the major pharmacological effects of DPP-IV inhibitors including hypoglycemic,cardiovascular system preservation,anti-inflammatory actions,etc.have been summarized through searching the related references at home and abroad.

关 键 词：二肽基肽酶IV抑制剂 2型糖尿病 降糖 保护心脏 抗炎作用 

分 类 号：R97[医药卫生—药品]