变叶树参根醋酸乙酯部位化学成分研究  

Chemical constituents in ethyl acetate fraction from roots of Dendropanax proteus

作　　者：李陆军[1] 宋杰 冯丽彬[1] 

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]北京协和制药二厂,北京102600

出　　处：《现代药物与临床》2013年第2期144-146,共3页Drugs & Clinic

摘　　要：目的研究五加科树参属植物变叶树参Dendropanax proteus根醋酸乙酯部位的化学成分。方法利用硅胶和Sephadex LH-20等色谱技术进行分离纯化,根据NMR、MS等波谱数据和理化性质鉴定化合物结构。结果从变叶树参根95%乙醇提取物的醋酸乙酯萃取部位分离鉴定了6个化合物,分别为3,5-二甲氧基-4-羟基反式桂皮醛(1)、3-甲氧基-4-羟基反式桂皮醛(2)、香草酸(3)、香草醛(4)、壬二酸(5)和β-谷甾醇(6)。结论化合物1～5为首次从该属植物中分离得到。Objective To study the chemical constituents from the roots of Dendropanax proteus.Methods The chemical constituents were isolated and purified by silica gel and Sephadex LH-20 column chromatography.Their structures were identified on the basis of spectroscopic data,such as NMR,MS,and physicochemical properties.Results Six compounds were isolated from the ethyl acetate fraction in 95% EtOH extract of D.proteus and identified as 3,5-dimethoxy-4-hydroxy-（E）-cinnamaldehyde（1）,3-methoxy-4-hydroxy-（E）-cinnamaldehyde（2）,vanillic acid（3）,vanillin（4）,1,9-nonanedioic acid（5）,and β-sitostero1（6）.Conclusion Compounds 1—5 are isolated from the plants of this genus for the first time.

关 键 词：变叶树参 3 5-二甲氧基-4-羟基反式桂皮醛 3-甲氧基-4-羟基反式桂皮醛 香草醛 香草酸 

分 类 号：R284.1[医药卫生—中药学]